Yener K, Hayat A
Department of Surgery, Faculty of Veterinary Medicine, Harran University, Akçakale Street Eyyübiye Campus 255 AN 63200 Eyyübiye/Şanlıurfa, Turkey.
Pol J Vet Sci. 2025 Jun;28(2):213-223. doi: 10.24425/pjvs.2025.154940.
This study aimed to evaluate the effects of tideglusib and bone graft mixture on bone healing. Tideglusib is a drug used in the treatment of various neurological disorders such as Alzheimer's disease. In a relevant study, the positive effect of tideglusib on the Wnt pathway, one of the pathways involved in bone regeneration and dentin tissue regeneration, was demonstrated. Dentin and bone tissues have structurally similar healing mechanisms. Therefore, tideglusib may have a similar effect on the bone tissue. The main goal of bone grafting is to provide bone regeneration and functional healing through remodeling. Bone graft materials are divided into four types based on their source: autogenous, allogenous, xenogenous, and alloplastic. Because these graft materials have various advantages and disadvantages, research continues to focus on alternative materials and applications. Sixteen New Zealand rabbits were included in this study. A unicortical 3.5 mm diameter defect was created in the tibia of rabbits under general anesthesia. The groups in the study were as follows: Group 1, left proximal tibia defect area was controlled (defect area was left empty); Group 2, left distal tibia defect area was treated with tideglusib + calcium sulfate; Group 3, right proximal tibia defect area was treated with calcium sulfate only; Group 4, right distal tibia defect area was treated with tideglusib only. Mediolateral (M/L) radiographs of the tibia were taken on the 30th and 60th postoperative days. On the 30th day, the first eight rabbits were sacrificed, and on the 60th day, the remaining eight were sacrificed for histopathological examination. New bone formation in the obtained samples was evaluated by radiological and histopathological analyses. The study concluded that the combination of tideglusib and calcium sulfate significantly enhanced bone healing compared with the other groups (p<0.005). This suggests that tideglusib, either alone or in combination with bone graft materials, could serve as a promising alternative for the repair of bone defects.
本研究旨在评估替格瑞洛和骨移植混合物对骨愈合的影响。替格瑞洛是一种用于治疗各种神经疾病（如阿尔茨海默病）的药物。在一项相关研究中，已证实替格瑞洛对Wnt信号通路有积极作用，Wnt信号通路是参与骨再生和牙本质组织再生的信号通路之一。牙本质和骨组织具有结构相似的愈合机制。因此，替格瑞洛可能对骨组织有类似作用。骨移植的主要目标是通过重塑实现骨再生和功能愈合。骨移植材料根据其来源分为四类：自体骨、异体骨、异种骨和人工合成骨。由于这些移植材料有各种优缺点，研究仍继续聚焦于替代材料及应用。本研究纳入了16只新西兰兔。在全身麻醉下，于兔胫骨制造一个直径3.5mm的单皮质缺损。研究分组如下：第1组，左胫骨近端缺损区域不做处理（缺损区域保持空置）；第2组，左胫骨远端缺损区域用替格瑞洛+硫酸钙治疗；第3组，右胫骨近端缺损区域仅用硫酸钙治疗；第4组，右胫骨远端缺损区域仅用替格瑞洛治疗。术后第30天和第60天拍摄胫骨的内外侧（M/L）X线片。术后第30天，处死前8只兔子，术后第60天，处死其余8只兔子进行组织病理学检查。通过放射学和组织病理学分析评估所获样本中的新骨形成情况。该研究得出结论，与其他组相比，替格瑞洛和硫酸钙联合使用能显著促进骨愈合（p<0.0
