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EI24与胰岛素样生长因子1受体（IGF1R）结合，增强雄性小鼠的葡萄糖稳态并促进健康衰老。

EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice.

作者信息

Kim You-Min, Lee Seung Eon, Song Yaechan, Nam Tae Wook, Lee Jaehoon, Seong Je Kyung, Namkung Wan, Lee Han-Woong

机构信息

Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

Gemcro, Inc., Seoul, Republic of Korea.

出版信息

Front Aging. 2025 Jun 10;6:1564730. doi: 10.3389/fragi.2025.1564730. eCollection 2025.

DOI:10.3389/fragi.2025.1564730
PMID:40556865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12185461/
Abstract

INTRODUCTION

The etoposide-induced 2.4 kb transcript (EI24) plays a crucial role in autophagy, facilitating the clearance of damaged proteins and organelles to maintain cellular homeostasis. While autophagy is widely recognized for its beneficial effects on healthy aging, the effects of EI24 overexpression remain unclear.

METHODS

We analyzed the interaction of EI24 with the insulin-like growth factor 1 receptor (IGF1R), a key molecule associated with aging. transgenic (TG) mice were generated to assess the effects of Ei24 overexpression on aging, glucose homeostasis, and resistance to streptozotocin (STZ)-induced diabetes.

RESULTS

EI24 was found to bind to IGF1R, specifically engaging with its transmembrane (TM) domain near the cytoplasmic membrane, and suppress its phosphorylation. Male  TG mice exhibited signs of healthier aging, with reduced aging markers in the kidney, liver, and pancreas. Moreover, Ei24 overexpression enhanced glucose uptake, likely due to increased Glut4 expression in muscle tissue.  TG mice also demonstrated resistance to high-dose STZ-induced diabetes.

CONCLUSION

These findings suggest that Ei24 overexpression contributes to improved glucose regulation and healthier aging across multiple organs. By interacting with IGF1R, EI24 may provide a novel mechanism for promoting metabolic and age-related health.

摘要

引言

依托泊苷诱导的2.4 kb转录本（EI24）在自噬中起关键作用，促进受损蛋白质和细胞器的清除以维持细胞内稳态。虽然自噬因其对健康衰老的有益作用而被广泛认可，但EI24过表达的影响仍不清楚。

方法

我们分析了EI24与胰岛素样生长因子1受体（IGF1R）的相互作用，IGF1R是一种与衰老相关的关键分子。构建转基因（TG）小鼠以评估Ei24过表达对衰老、葡萄糖稳态以及对链脲佐菌素（STZ）诱导的糖尿病的抗性的影响。

结果

发现EI24与IGF1R结合，特异性地与靠近细胞质膜的跨膜（TM）结构域相互作用，并抑制其磷酸化。雄性TG小鼠表现出更健康的衰老迹象，肾脏、肝脏和胰腺中的衰老标志物减少。此外，Ei24过表达增强了葡萄糖摄取，这可能是由于肌肉组织中Glut4表达增加所致。TG小鼠对高剂量STZ诱导的糖尿病也具有抗性。

结论

这些发现表明，Ei24过表达有助于改善多个器官的葡萄糖调节并促进更健康的衰老。通过与IGF1R相互作用，EI24可能为促进代谢和与年龄相关的健康提供一种新机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/4845b3007ed0/fragi-06-1564730-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/3a93132dc41f/fragi-06-1564730-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/d56f8a647d1c/fragi-06-1564730-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/496468b41b5b/fragi-06-1564730-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/4845b3007ed0/fragi-06-1564730-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/3a93132dc41f/fragi-06-1564730-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/d56f8a647d1c/fragi-06-1564730-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/496468b41b5b/fragi-06-1564730-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/12185461/4845b3007ed0/fragi-06-1564730-g004.jpg

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本文引用的文献

1
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Geroscience. 2024 Apr;46(2):2653-2670. doi: 10.1007/s11357-023-01025-8. Epub 2023 Dec 19.
2
Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.IGF1R 减少可减弱胰腺 β 细胞衰老并改善其功能。
Front Endocrinol (Lausanne). 2023 Jun 27;14:1203534. doi: 10.3389/fendo.2023.1203534. eCollection 2023.
3
Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation.
局部生长激素受体在成肌细胞分化过程中通过线粒体生物发生调节线粒体功能中的作用。
Cell Commun Signal. 2023 Jun 19;21(1):148. doi: 10.1186/s12964-023-01166-5.
4
Targeting IGF1R signaling for brain aging and Alzheimer's disease.针对胰岛素样生长因子1受体（IGF1R）信号传导治疗脑衰老和阿尔茨海默病。
Aging Pathobiol Ther. 2022;4(4):129-131. doi: 10.31491/apt.2022.12.103. Epub 2022 Dec 29.
5
IGF1R is a mediator of sex-specific metabolism in mice: Effects of age and high-fat diet.IGF1R 是雌雄鼠代谢性别特异性的中介：年龄和高脂肪饮食的影响。
Front Endocrinol (Lausanne). 2022 Oct 20;13:1033208. doi: 10.3389/fendo.2022.1033208. eCollection 2022.
6
EI24 promotes cell adaption to ER stress by coordinating IRE1 signaling and calcium homeostasis.EI24 通过协调 IRE1 信号和钙稳态促进细胞适应内质网应激。
EMBO Rep. 2022 Feb 3;23(3):e51679. doi: 10.15252/embr.202051679. Epub 2022 Jan 10.
7
Autophagy in healthy aging and disease.自噬在健康衰老和疾病中的作用。
Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12.
8
Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.核沉默调节蛋白SIRT6在骨骼肌中的特异性过表达通过调控多个靶点来阻止癌症相关性恶病质。
JCSM Rapid Commun. 2021 Jan-Jun;4(1):40-56. doi: 10.1002/rco2.27. Epub 2020 Dec 23.
9
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Mol Metab. 2021 Oct;52:101245. doi: 10.1016/j.molmet.2021.101245. Epub 2021 May 4.
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Cell Death Dis. 2020 Sep 9;11(9):732. doi: 10.1038/s41419-020-02937-5.