Siregar Ginanda Putra, Parwati Ida, Safriadi Ferry, Tjahjodjati Tjahjodjati
Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Division of Urology, Department of Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
World J Oncol. 2025 Jun;16(3):295-298. doi: 10.14740/wjon2515. Epub 2025 Jun 14.
One of the most common cancers is bladder cancer, characterized by a high mortality rate and a high incidence of recurrence. An identified susceptibility factor for bladder cancer is the presence of single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor () genes, specifically -2578C>A and -7C>T polymorphisms.
This pilot study was conducted to uncover the association between the SNP -2578C>A and -7C>T in bladder cancer. A total of 20 patients were tested, consisting of both 10 controls and patients with bladder cancer, for the SNP of -2578C>A and -7C>T through polymerase chain reaction (PCR).
This study showed a significant association between the -2578C>A polymorphism (odds ratio (OR) 1.93, 95% confidence interval (CI) 1.03 - 2.01) and an increased risk of bladder cancer, especially in individuals with the A allele. However, the results for the -7C>T polymorphism in relation to bladder cancer risk showed a non-significant association in this study population. We did not detect a significant association between the -2578C>A (OR 0.93 (0.39 - 2.01)) and -7C>T (OR 0.74 (0.32 - 1.57)) polymorphisms and bladder cancer severity, as indicated by stages.
This pilot study suggests that -2578C>A has a connection between polymorphism and bladder cancer susceptibility. Further large-scale studies need to be done to validate these findings and elucidate the underlying mechanisms linking polymorphisms to bladder cancer pathogenesis.
膀胱癌是最常见的癌症之一，其特征是死亡率高和复发率高。已确定的膀胱癌易感因素是血管内皮生长因子（VEGF）基因中存在单核苷酸多态性（SNP），特别是-2578C>A和-7C>T多态性。
本初步研究旨在揭示膀胱癌中SNP -2578C>A和-7C>T之间的关联。通过聚合酶链反应（PCR）对总共20名患者进行了检测，其中包括10名对照和膀胱癌患者，检测-2578C>A和-7C>T的SNP。
本研究表明，-2578C>A多态性（优势比（OR）1.93，95%置信区间（CI）1.03 - 2.01）与膀胱癌风险增加之间存在显著关联，尤其是携带A等位基因的个体。然而，在本研究人群中，-7C>T多态性与膀胱癌风险的结果显示无显著关联。我们未检测到-2578C>A（OR 0.93（0.39 - 2.01））和-7C>T（OR 0.74（0.32 - 1.57））多态性与按阶段所示的膀胱癌严重程度之间存在显著关联。
本初步研究表明，-2578C>A多态性与膀胱癌易感性之间存在联系。需要进一步开展大规模研究以验证这些发现，并阐明将VEGF多态性与膀胱癌发病机制联系起来的潜在机制。
