State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
Urology. 2010 Sep;76(3):765.e1-7. doi: 10.1016/j.urology.2010.04.044. Epub 2010 Jul 13.
To perform a meta-analysis to explore a more robust estimate of the effect of the TP53 Arg72Pro polymorphism on bladder cancer risk. Studies investigating the association between TP53 Arg72Pro polymorphism and bladder cancer risk have reported conflicting results.
All eligible studies were searched in PubMed. The quality of the studies was evaluated according to a predefined scale. Crude odds ratios, with the 95% confidence intervals, were assessed for the association using fixed- and random-effects models.
We identified 10 case-control studies involving 3549 subjects for the present meta-analysis. Overall, no evidence of an association was observed between the TP53 genotypes and bladder cancer susceptibility when all the studies were pooled into the meta-analysis. However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians. In contrast, no effect of this polymorphism on bladder cancer in whites, Africans, or other population was observed when only high-quality scored studies were considered.
The results of the present meta-analysis suggest that the TP53 Arg72 allele is a protective factor and that the Pro/Pro genotype might increase the susceptibility to bladder cancer in Asians. The conflicting findings among studies might have resulted from variations in the allele frequencies among the different races, as well as the methodologic quality of the studies.
进行荟萃分析，以探索更稳健的 TP53 Arg72Pro 多态性对膀胱癌风险影响的估计值。研究膀胱癌风险与 TP53 Arg72Pro 多态性之间关系的研究报告结果相互矛盾。
在 PubMed 中搜索所有符合条件的研究。根据预定的标准评估研究的质量。使用固定效应和随机效应模型评估关联的粗比值比及其 95%置信区间。
我们确定了 10 项病例对照研究，涉及 3549 名受试者进行本次荟萃分析。总体而言，当所有研究合并到荟萃分析中时，TP53 基因型与膀胱癌易感性之间没有关联的证据。然而，TP53 基因型 Arg/Arg 与 Pro/Pro（比值比 0.74，95%置信区间 0.55-0.99）和 Arg/Arg 加 Arg/Pro 与 Pro/Pro（比值比 0.77，95%置信区间 0.59-1.00）相比，亚洲人患膀胱癌的风险显著降低。相比之下，当仅考虑高质量评分的研究时，该多态性对白人、非洲人或其他人群的膀胱癌没有影响。
本荟萃分析的结果表明，TP53 Arg 等位基因是一个保护因素，Pro/Pro 基因型可能会增加亚洲人患膀胱癌的易感性。研究结果之间的矛盾可能是由于不同种族之间等位基因频率的差异以及研究方法学质量的差异所致。
