Zhao Zhi-Qiang, An Xue-Rui, Tian Xue, Zhou Heng-Wei, Li Tian-Zhi, Liu Wei, Yuan Tao
Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Yining 835000, China.
Xinjiang Laboratory of Phase Transition and Microstructures in Condensed Matter physics, Yili Normal University, Yining 835000, China.
Org Lett. 2025 Jul 4;27(26):7116-7119. doi: 10.1021/acs.orglett.5c02010. Epub 2025 Jun 25.
Two unprecedented ring-B -norcucurbitane triterpenoids, norcolocynins A () and B (), were isolated from fruits. The determination of their structures was based on the extensive analysis of spectroscopic data as well as X-ray crystallography. A biogenetic route for involving a decarboxylation, followed by a rearrangement of is proposed. Cytotoxicity assay revealed that showed moderate activity against HCT116 cells (IC = 27.92 ± 0.80 μM), comparable to that of positive control cisplatin.
从果实中分离出了两种前所未有的环-B-降葫芦烷三萜，即降苦瓜子素A（）和降苦瓜子素B（）。它们结构的确定基于光谱数据的广泛分析以及X射线晶体学。提出了一种涉及脱羧，随后进行重排的生源合成途径。细胞毒性试验表明，对HCT116细胞显示出中等活性（IC = 27.92±0.80 μM），与阳性对照顺铂相当。
