Abedi Arian Ocean, Abedi Armita Armina, Ferry Tristan, Citak Mustafa
Department of Orthopaedic Surgery, Helios Endo-Klinik Hamburg, 22767 Hamburg, Germany.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Antibiotics (Basel). 2025 Jun 6;14(6):581. doi: 10.3390/antibiotics14060581.
Periprosthetic joint infections (PJI) present significant challenges in orthopedic surgery, largely due to the complexity of treating antibiotic-resistant infections. Phage therapy, which utilizes bacteriophages to target bacterial pathogens, offers a promising supplement to traditional antimicrobial methods. This review discusses the current applications of phage therapy in the management of PJI, exploring its underlying mechanisms, clinical outcomes, and practical considerations. We also explore advances in phage therapy technology, including the development of phage cocktails, bioengineered phages, and combination therapies with antibiotics, which enhance the specificity and effectiveness of treatments. Furthermore, we address the future potential of phage therapy to be integrated into standard treatment protocols, focusing on ongoing innovations and research areas.The regulatory and ethical aspects of phage therapy in clinical settings are also discussed. By offering a comprehensive evaluation of both the current state and prospects of phage therapy, this review aims to inform clinical practice and stimulate further research into this innovative treatment modality for PJI management.
人工关节周围感染（PJI）在骨科手术中带来了重大挑战，这主要归因于治疗耐抗生素感染的复杂性。噬菌体疗法利用噬菌体靶向细菌病原体，为传统抗菌方法提供了一种有前景的补充。本文综述讨论了噬菌体疗法在PJI管理中的当前应用，探讨了其潜在机制、临床结果和实际考虑因素。我们还探讨了噬菌体疗法技术的进展，包括噬菌体鸡尾酒、生物工程噬菌体的开发以及与抗生素的联合疗法，这些都提高了治疗的特异性和有效性。此外，我们关注噬菌体疗法融入标准治疗方案的未来潜力，重点关注正在进行的创新和研究领域。还讨论了临床环境中噬菌体疗法的监管和伦理方面。通过对噬菌体疗法的现状和前景进行全面评估，本文综述旨在为临床实践提供信息，并激发对这种用于PJI管理的创新治疗方式的进一步研究。
