Munteanu Daniela I, Dunn John, Apjok Gábor, Kintses Bálint, Griselain Johann, Steurs Griet, Cochez Christel, Djebara Sarah, Merabishvili Maya, Pirnay Jean-Paul, Štilec Vida, Peterka Matjaž, Simpson Emily A, Downie Samantha, MacInnes Alasdair, Nicol Graeme, Clift Benedict, Jones Joshua D
Department of Medical Microbiology, Ninewells Hospital, Dundee DD1 9SY, UK.
Pharmacy Department, Ninewells Hospital, Dundee DD1 9SY, UK.
Antibiotics (Basel). 2025 Jan 22;14(2):114. doi: 10.3390/antibiotics14020114.
: Bacteriophages (phages) are viruses that infect and kill bacteria. The antimicrobial resistance crisis has driven renewed interest in phage therapy, including the use of phages to treat chronic orthopaedic infections. : Here, we present the results of the first three orthopaedic patients treated with phage therapy in the United Kingdom. : The first patient was treated in May 2023 and received phages active against . At nine months follow-up, the patient's wound remained healed, the C-reactive protein normal and the patient was walking independently. The second patient received phages active against and ; the infection remained unresolved. The third patient received phages active against ; at six months follow-up, the patient was free of infection. Endotoxin was considered at least partially responsible for mild self-limiting adverse effects in two cases. : These promising results hint at the potential for phage therapy to transform the care of chronic orthopaedic infections.
噬菌体是感染并杀死细菌的病毒。抗菌药物耐药性危机重新激发了人们对噬菌体疗法的兴趣，包括使用噬菌体治疗慢性骨科感染。在此，我们展示了英国首批三名接受噬菌体疗法的骨科患者的治疗结果。第一名患者于2023年5月接受治疗，接受了对……有活性的噬菌体。在九个月的随访中，患者的伤口保持愈合，C反应蛋白正常，患者能够独立行走。第二名患者接受了对……和……有活性的噬菌体；感染仍未解决。第三名患者接受了对……有活性的噬菌体；在六个月的随访中，患者没有感染。内毒素被认为至少部分导致了两例轻度自限性不良反应。这些有前景的结果暗示了噬菌体疗法改变慢性骨科感染治疗的潜力。
