Terashima Miyu, Nakayama Kota, Ugai Satoko, Lee Hwa-Young, Tsukumo Yuta, Suzuki Etsuji, Mizuno Hiroki, Song Minkyo, Sasamoto Naoko, Kawachi Ichiro, Ugai Tomotaka
Okayama University Medical School, Okayama 700-8558, Japan.
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.
Curr Oncol. 2025 May 31;32(6):324. doi: 10.3390/curroncol32060324.
The global rise in obesity prevalence and the incidence of early-onset cancer (diagnosed between 20 and 49 years of age) is a serious public health concern. We, therefore, evaluated the recent global trends in the incidence of early-onset obesity-related cancers and compared them to those of non-obesity-related cancers. We obtained age-standardized incidence rates of early-onset cancers diagnosed between 2000 and 2012 in 44 countries from the Cancer Incidence in Five Continents database. Using joinpoint regression models, we calculated the average annual percentage changes (AAPCs) and their corresponding 95% confidence intervals (95% CIs) for combined and individual categories of obesity-related cancers (11 and 9 cancer types in females and males, respectively) and non-obesity-related cancers (12 cancer types in both females and males). Differences in the AAPC were assessed by comparing 95% CIs, where nonoverlapping 95% CIs were considered statistically significantly different. We observed statistically significant positive AAPCs for early-onset obesity-related cancers in all available countries combined among females (global AAPC, 4.3%; 95% CI, 4.1-4.6%) and males (global AAPC, 1.4%; 95% CI, 1.2-1.7%). When analyzed by countries, we observed statistically significant positive AAPCs in 26 countries among females and 11 countries among males. AAPCs for early-onset obesity-related cancers were statistically significantly higher than those of non-obesity-related cancers in several regions, especially North America and Oceania. In conclusion, this study indicates that the incidence of early-onset obesity-related cancers exhibited a more pronounced increasing trend than non-obesity-related cancers among both sexes in many countries and regions.
全球肥胖患病率的上升以及早发性癌症（20至49岁之间确诊）的发病率是一个严重的公共卫生问题。因此，我们评估了近期全球早发性肥胖相关癌症发病率的趋势，并将其与非肥胖相关癌症的发病率趋势进行比较。我们从《五大洲癌症发病率》数据库中获取了2000年至2012年间44个国家早发性癌症的年龄标准化发病率。使用Joinpoint回归模型，我们计算了肥胖相关癌症（女性和男性分别为11种和9种癌症类型）和非肥胖相关癌症（女性和男性均为12种癌症类型）综合及各分类的平均年百分比变化（AAPC）及其相应的95%置信区间（95%CI）。通过比较95%CI评估AAPC的差异，其中不重叠的95%CI被认为具有统计学显著差异。我们观察到，在所有可用国家中，女性早发性肥胖相关癌症的AAPC具有统计学显著的正向变化（全球AAPC，4.3%；95%CI，4.1 - 4.6%），男性也是如此（全球AAPC，1.4%；95%CI，1.2 - 1.7%）。按国家分析时，我们观察到女性中有26个国家、男性中有11个国家的AAPC具有统计学显著的正向变化。在几个地区，尤其是北美和大洋洲，早发性肥胖相关癌症的AAPC在统计学上显著高于非肥胖相关癌症。总之，本研究表明，在许多国家和地区，早发性肥胖相关癌症的发病率比非肥胖相关癌症呈现出更明显的上升趋势。
