Moussa Carol, Estrade Laurent, Glomet Jeremy, Rochefort Gael Y, Denis Frédéric, Daou Maha H
Faculty of Dentistry, University of Tours, 37032 Tours, France.
Division of Education, Ethics, Health, Faculty of Medicine, University of Tours, 37044 Tours, France.
Diseases. 2025 Jun 16;13(6):186. doi: 10.3390/diseases13060186.
: Cancer patients undergoing chemotherapy (CT) or radiotherapy (RT) are at increased risk of oral complications. Preventive dental care has been proposed to mitigate these risks, yet its effectiveness is not sufficiently evaluated. This systematic review and meta-analysis aimed to assess the impact of preventive oral health interventions on key clinical outcomes in oncology patients. : A systematic search of MEDLINE, Embase, and CENTRAL databases was conducted (March 2025), adhering to PRISMA guidelines with a PROSPERO-registered protocol (CRD 420251006799). Eligible studies included randomized trials, cohort studies, and pre-post intervention studies evaluating preventive dental care in patients receiving CT or RT. The outcomes included gingival index (GI), dental caries (DMFT), plaque levels, and periodontal health. Meta-analyses were performed on GI and DMFT outcomes using random-effects models. : Eleven studies were included in the qualitative synthesis and four in the meta-analyses. Preventive interventions, such as fluoride applications, oral hygiene education, and regular professional cleanings, were associated with stabilization or improvement of gingival health. The pooled estimate for GI showed no significant deterioration over time (MD = -0.05, 95% CI: -0.34 to 0.24, = 0.72). For DMFT, a slight but significant increase was observed (MD = 1.07, 95% CI: 0.08 to 2.05, = 0.03), suggesting a continued risk of caries despite intervention. : Preventive dental care interventions appear to support the maintenance of gingival health in cancer patients undergoing CT or RT. However, despite these interventions, a slight increase in dental caries was still observed, indicating that preventive strategies may not fully eliminate the risk of caries. These findings highlight the importance of sustained and individualized oral health programs as part of comprehensive oncology care. Future studies using standardized protocols and longer follow-up periods are needed to better evaluate their long-term effectiveness across diverse cancer populations.
接受化疗（CT）或放疗（RT）的癌症患者出现口腔并发症的风险增加。已提出预防性口腔护理以减轻这些风险，但其有效性尚未得到充分评估。本系统评价和荟萃分析旨在评估预防性口腔健康干预对肿瘤患者关键临床结局的影响。：对MEDLINE、Embase和CENTRAL数据库进行了系统检索（2025年3月），遵循PRISMA指南并采用PROSPERO注册方案（CRD 420251006799）。符合条件的研究包括评估接受CT或RT患者的预防性口腔护理的随机试验、队列研究和干预前后研究。结局包括牙龈指数（GI）、龋齿（DMFT）、牙菌斑水平和牙周健康。使用随机效应模型对GI和DMFT结局进行荟萃分析。：定性综合纳入了11项研究，荟萃分析纳入了4项研究。氟化物应用、口腔卫生教育和定期专业清洁等预防性干预措施与牙龈健康的稳定或改善有关。GI的合并估计显示随时间无显著恶化（MD = -0.05，95%CI：-0.34至0.24，I² = 0.72）。对于DMFT，观察到轻微但显著的增加（MD = 1.07，95%CI：0.08至2.05，I² = 0.03），表明尽管进行了干预，龋齿风险仍持续存在。：预防性口腔护理干预似乎有助于接受CT或RT的癌症患者维持牙龈健康。然而，尽管采取了这些干预措施，仍观察到龋齿略有增加，这表明预防性策略可能无法完全消除龋齿风险。这些发现凸显了持续的个性化口腔健康计划作为综合肿瘤护理一部分的重要性。需要使用标准化方案和更长随访期的未来研究，以更好地评估其在不同癌症人群中的长期有效性。
