Mpuhua Casanova André Motopa, Souza Orivaldo Florencio de, Daboin Blanca Elena Guerrero, Bezerra Italla Maria Pinheiro, Na Blei Marcelino, Sarti Thiago Dias, Silva Vithor Ely Bortolin da, Abreu Luiz Carlos de
Centro de Ciências da Saúde, Universidade Federal do Espírito Santos (UFES), Vitoria 29075-910, ES, Brazil.
Centro de Ciências da Saúde e do Desporto, Universidade Federal do Acre (UFAC), Rio Branco 69920-900, AC, Brazil.
Epidemiologia (Basel). 2025 Jun 19;6(2):28. doi: 10.3390/epidemiologia6020028.
Stroke is one of the leading causes of death and disability worldwide. In Brazil, it remains the primary cause of mortality among adults. Although overall stroke mortality rates have declined, the absolute number of stroke incidents, deaths, and years of life loss continues to rise, particularly in developing and underdeveloped countries. The aim of this study was to analyze trends in stroke mortality across different age groups and both sexes in Espírito Santo, Brazil, from 2000 to 2021. This ecological time series study utilized secondary data from Espírito Santo, Brazil, from 2000 to 2021. Mortality data, categorized by sex and age group, were obtained from the Department of Informatics of the Unified Health System (DATASUS) database. Stroke-related mortality included deaths recorded under the International Classification of Diseases, 10th Revision (ICD-10) codes for subarachnoid hemorrhage (I60), intracerebral hemorrhage (I61), cerebral infarction (I63), and stroke not specified as hemorrhagic or ischemic (I64). Temporal trends in stroke mortality were assessed using joinpoint regression analysis. From 2000 to 2021, there was a significant reduction in proportional mortality from stroke, with an overall decrease of -3.7% ( < 0.001). When analyzed by sex, the decline was -3.0% ( < 0.001) for males and -3.9% ( < 0.001) for females. The most significant decrease in proportional mortality was observed in the 50 to 59 age group, with an average annual percentage change of -4.9% ( < 0.001). The 30 to 39 age group exhibited the smallest decline, with an average annual percentage change of -2.4% ( < 0.001). No significant segments were observed in the 40 to 49, 60 to 69, and 70 to 79 age groups during the study period. This study identified a notable decline in stroke-related proportional mortality in the adult population of Espírito Santo between 2000 and 2021. While males had a higher absolute number of deaths, females exhibited a higher proportional mortality rate, underscoring the need for targeted preventive measures and effective acute stroke treatment, particularly among men.
中风是全球主要的死亡和残疾原因之一。在巴西，它仍然是成年人死亡的主要原因。尽管中风的总体死亡率有所下降，但中风事件、死亡和生命损失年数的绝对数量仍在上升，特别是在发展中国家和不发达国家。本研究的目的是分析2000年至2021年巴西圣埃斯皮里图州不同年龄组和男女的中风死亡率趋势。这项生态时间序列研究利用了巴西圣埃斯皮里图州2000年至2021年的二手数据。按性别和年龄组分类的死亡率数据来自统一卫生系统信息部（DATASUS）数据库。与中风相关的死亡率包括根据国际疾病分类第10版（ICD-10）编码记录的蛛网膜下腔出血（I60）、脑出血（I61）、脑梗死（I63）以及未明确为出血性或缺血性的中风（I64）的死亡。使用连接点回归分析评估中风死亡率的时间趋势。2000年至2021年期间，中风的比例死亡率显著下降，总体下降了-3.7%（<0.001）。按性别分析，男性下降了-3.0%（<0.001），女性下降了-3.9%（<0.001）。比例死亡率下降最显著的是50至59岁年龄组，平均年度百分比变化为-4.9%（<0.001）。30至39岁年龄组下降最小，平均年度百分比变化为-2.4%（<0.001）。在研究期间，40至49岁、60至69岁和70至79岁年龄组未观察到显著变化。本研究发现，2000年至2021年期间，圣埃斯皮里图州成年人口中与中风相关的比例死亡率显著下降。虽然男性的绝对死亡人数较多，但女性的比例死亡率较高，这突出表明需要采取有针对性的预防措施和有效的急性中风治疗方法，特别是在男性中。
