Faccin Izadora Dillis, Salomé Túlio Máximo, de Almeida de Souza Gleyce Hellen, da Costa Xavier Leonardo, Alves Izabel Almeida, Lima Vanessa Castro Felix, Lucini Fabíola, Simionatto Simone, Rossato Luana
Health Sciences Research Laboratory, Universidade Federal of Grande Dourados, 79804-970 Dourados, Brazil.
Pharmacokinetics and Pharmacometrics Laboratory, Universidade Federal da Bahia, 40110-909 Salvador, Brazil.
J Fungi (Basel). 2025 Jun 18;11(6):463. doi: 10.3390/jof11060463.
Fusariosis is an infection caused by the fungus spp., which is pathogenic to both plants and humans. The disease presents several clinical manifestations and epidemiological patterns. Current treatment relies on azoles and polyenes, but increasing antifungal resistance requires the exploration of new therapeutic options. This study reviewed patents related to the treatment of Fusariosis from the last 15 years (up to June 2023). The search identified 318 patents, categorized by identification code, publication date, type of application and mechanism of action, using the International Patent Classification and Cooperative Patent Classification systems. In addition, we conducted a bibliographic search in the PubMed database using the same criteria to identify the number of scientific articles. Of the 318 patents, 21 targeted Fusarium infections in humans. The years 2014 and 2018 stood out with three patents each, while the same period recorded an average of 58 published articles. The patents addressed mechanisms such as drug delivery, gene expression, immunotherapy, engineered drugs, and novel compounds. This research highlights the urgent need for continued innovation in therapeutic technologies to effectively treat wilt.
镰刀菌病是一种由镰刀菌属真菌引起的感染，这种真菌对植物和人类均具有致病性。该疾病呈现出多种临床表现和流行病学模式。目前的治疗依赖于唑类和多烯类药物，但不断增加的抗真菌耐药性促使人们探索新的治疗选择。本研究回顾了过去15年（截至2023年6月）与镰刀菌病治疗相关的专利。通过使用国际专利分类和合作专利分类系统，检索确定了318项专利，并按识别代码、公布日期、申请类型和作用机制进行了分类。此外，我们使用相同标准在PubMed数据库中进行了文献检索，以确定科学文章的数量。在这318项专利中，有21项针对人类镰刀菌感染。2014年和2018年各有三项专利脱颖而出，而同一时期平均有58篇发表文章。这些专利涉及药物递送、基因表达、免疫疗法、工程药物和新型化合物等机制。这项研究凸显了治疗技术持续创新以有效治疗镰刀菌病的迫切需求。
