Isleyen Hasan B, Kanar Batur G, Akcay Guzide, Demir Serdar, Kanar Hatice S, Yazicioglu Mehmet V
Cardiology Department, Istanbul Nişantaşı Üniversitesi, Istanbul 34475, Turkey.
Cardiology Department, School of Medicine, Istinye University, Istanbul 34396, Turkey.
J Pers Med. 2025 Jun 18;15(6):259. doi: 10.3390/jpm15060259.
: The aim of this study was to evaluate choroidal and peripapillary retinal nerve fiber layer (RNFL) thicknesses in individuals with vasovagal syncope (VVS). : A total of 67 consecutive patients with VVS and 61 healthy control subjects were enrolled this study. The choroidal thickness (CT) at the fovea, the nasal to fovea thickness, and the temporal to fovea thickness were measured, alongside pRNLFT measurements assessed by swept-source optical coherence tomography (SS-OCT). : The mean foveal CT (408.7 ± 92.5 μm vs. 342.1 ± 60.2 μm, < 0.01), the mean nasal CT (385.2 ± 88.3 μm vs. 329.2 ± 47.6 μm, < 0.001), and the mean temporal CT (379.5 ± 51.6 μm vs. 321.48 ± 43.2 μm, < 0.03) were statistically thicker in patients with VVS compared to the healthy controls. There was no statistically significant difference in the global pRNFLT measurements and all quadrants between the study groups. : The CT in all regions was found to be thicker in patients with VVS compared to the healthy controls, while there were no differences in pRNFLT values. These results suggest that choroidal circulation might be affected by local neurotransmitter alterations in patients with VVS.
本研究旨在评估血管迷走性晕厥（VVS）患者的脉络膜和视乳头周围视网膜神经纤维层（RNFL）厚度。本研究共纳入67例连续的VVS患者和61例健康对照者。通过扫频光学相干断层扫描（SS-OCT）测量了黄斑中心凹处的脉络膜厚度（CT）、黄斑中心凹鼻侧厚度和黄斑中心凹颞侧厚度，同时评估了pRNLFT。与健康对照组相比，VVS患者的平均黄斑中心凹CT（408.7±92.5μm对342.1±60.2μm，<0.01）、平均鼻侧CT（385.2±88.3μm对329.2±47.6μm，<0.001）和平均颞侧CT（379.5±51.6μm对321.48±43.2μm，<0.03）在统计学上更厚。研究组之间的整体pRNFLT测量值和所有象限均无统计学显著差异。与健康对照组相比，VVS患者所有区域的CT均更厚，而pRNFLT值无差异。这些结果表明，VVS患者的脉络膜循环可能受局部神经递质改变的影响。
