Novoa-Moreno Ana Lorena, Martinez-Jimenez Mario Aurelio, Ortiz-Alvarez Arturo, Sanchez-Olivo Natalia, Loza-Gonzalez Victor Manuel, Ramirez-GarciaLuna Jose Luis
Wound Clinic of the Regional High-Specialty Hospital "Ignacio Morones Prieto", San Luis Potosí 78220, SLP, Mexico.
Infectology Department of the Regional High-Specialty Hospital "Ignacio Morones Prieto", San Luis Potosí 78220, SLP, Mexico.
Infect Dis Rep. 2025 Jun 19;17(3):72. doi: 10.3390/idr17030072.
Impetigo is a highly contagious bacterial skin infection characterized by blistering and erosions that can lead to significant discomfort and complications. The standard treatment includes topical or systemic antibiotics, but severe cases may require advanced wound management strategies. Polylactic acid (PLA)-based membranes have demonstrated effectiveness in enhancing wound healing, modulating inflammation, and reducing pain. We present three cases of bullous impetigo with extensive erosions, managed using PLA membranes as an adjunct to systemic antibiotics. A significant improvement was shown after 7 days of treatment of a single application, and complete resolution was achieved after 30 days. Notably, pain was resolved within 48-72 h, highlighting the analgesic and protective properties of the membrane. These findings suggest that PLA membranes provide a viable adjunct to antibiotic therapy in bullous impetigo, accelerating healing, reducing discomfort, and improving long-term skin outcomes. Given the increasing concern over antibiotic resistance and the limitations of standard wound care, bioresorbable synthetic membranes represent a promising alternative in dermatological wound management.
脓疱病是一种具有高度传染性的细菌性皮肤感染，其特征为水疱和糜烂，可导致严重不适和并发症。标准治疗包括局部或全身使用抗生素，但严重病例可能需要先进的伤口管理策略。基于聚乳酸（PLA）的膜已证明在促进伤口愈合、调节炎症和减轻疼痛方面有效。我们报告了3例伴有广泛糜烂的大疱性脓疱病病例，使用PLA膜作为全身抗生素治疗的辅助手段。单次应用治疗7天后显示出显著改善，30天后实现完全愈合。值得注意的是，疼痛在48 - 72小时内缓解，突出了该膜的镇痛和保护特性。这些发现表明，PLA膜为大疱性脓疱病的抗生素治疗提供了一种可行的辅助手段，可加速愈合、减轻不适并改善长期皮肤预后。鉴于对抗生素耐药性的日益关注以及标准伤口护理的局限性，可生物吸收的合成膜在皮肤病伤口管理中是一种有前景的替代方法。
