Hui Ling Chen, BS is Master of Philosophy Student, School of Nursing and Health Studies, Hong Kong Metropolitan University. Joanne Wai Yee Chung, PhD, RN, is Professor, Hong Kong Nang Yan College of Higher Education. Vincent Chun Man Yan, MSc, is Senior Lecturer, School of Nursing and Health Studies, Hong Kong Metropolitan University. Thomas Kwok Shing Wong, PhD, RN, is Professor, Hong Kong Nang Yan College of Higher Education. The authors have disclosed no financial relationships related to this article. Submitted August 18, 2022; accepted in revised form November 4, 2022; published ahead of print July 24, 2023.
Adv Skin Wound Care. 2023 Sep 1;36(9):1-8. doi: 10.1097/ASW.0000000000000011.
To examine (1) the effectiveness of polylactic acid (PLA)-based biomaterials in wound healing, (2) their effects on wound infection prevention, and (3) their safety compared with existing biomaterials.
Data sources included PubMed, MEDLINE, Cochrane Library, CINAHL (Cumulative Index to Nursing and Allied Health Literature), CNKI (China National Knowledge Infrastructure), WEIPU, and WANFANG databases.
Investigators included 14 studies discussing the effects of PLA-based biomaterials in cutaneous wound healing published from 2000 to 2021.
Authors extracted the following information from the selected studies: general information, study type, type of wound, PLA-based biomaterials and techniques, study period, outcome measures, and results.
Polylactic acid-based biomaterials may promote wound healing through wound area repair, collagen deposition, angiogenesis, and cell activities, which are related to the good biocompatibility, biodegradability, and moisture management properties of PLA. A proper product structure may also help. Both the native PLA materials and PLA blends seem to be antibacterial, although more evidence is needed for the native PLA products. Because there was no severe adverse event or obvious cytotoxicity observed in the included studies, PLA-based biomaterials are likely safe.
Polylactic acid-based biomaterials may be good wound dressing materials, although more evidence is needed to support their broader application in wound care.
考察（1）聚乳酸（PLA）基生物材料在伤口愈合中的有效性，（2）它们在预防伤口感染方面的作用，（3）与现有生物材料相比的安全性。
资料来源包括 PubMed、MEDLINE、Cochrane 图书馆、CINAHL（护理与联合健康文献累积索引）、CNKI（中国国家知识基础设施）、WEIPU 和 WANFANG 数据库。
研究人员纳入了 2000 年至 2021 年期间发表的 14 项讨论 PLA 基生物材料在皮肤伤口愈合中作用的研究。
作者从选定的研究中提取了以下信息：一般信息、研究类型、伤口类型、PLA 基生物材料和技术、研究期间、结果测量和结果。
聚乳酸基生物材料可能通过促进伤口面积修复、胶原蛋白沉积、血管生成和细胞活性来促进伤口愈合，这与 PLA 的良好生物相容性、可生物降解性和保湿性能有关。适当的产品结构也可能有帮助。天然 PLA 材料和 PLA 共混物似乎都具有抗菌作用，尽管天然 PLA 产品需要更多的证据。由于纳入的研究中没有观察到严重的不良事件或明显的细胞毒性，因此 PLA 基生物材料可能是安全的。
聚乳酸基生物材料可能是良好的伤口敷料材料，但需要更多的证据来支持其在伤口护理中的更广泛应用。
