Davis Carson C, Dias Panariello Fabrízio, Panariello Beatriz
School of Dental Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA.
School of Medical Sciences, São Leopoldo Mandic, Campinas 13045-755, SP, Brazil.
Med Sci (Basel). 2025 Jun 18;13(2):79. doi: 10.3390/medsci13020079.
The rise of antibiotic resistance and the limitations of conventional therapies for managing biofilm-related oral infections highlight the urgent need for novel solutions, with low-temperature plasma (LTP) emerging as a promising alternative due to its potent antimicrobial effects, tissue-safety, and reduced risk of fostering resistance. This scoping review investigates the efficacy of LTP application for the management of oral biofilms associated with dental caries, peri-implantitis, endodontic infections, and oral candidiasis. This review was conducted in accordance with the PRISMA-ScR guidelines and registered with the Open Science Framework (OSF). Studies were identified through comprehensive searches of PubMed/MEDLINE, EBSCO (Medline Ultimate and e-journals), and Google Scholar, with no publication date restrictions, and were supplemented by manual reference screening. Eligible studies included original research, published in English, examining LTP's effectiveness in oral biofilms. After systematically screening the literature, 51 studies were included in this scoping review, comprising mostly in vitro research, alongside ex vivo, in situ, and clinical studies. Data extraction revealed LTP's broad-spectrum antimicrobial potential and promising clinical implications for dentistry. This review highlights key findings, identifies research gaps, and underscores the therapeutic potential of LTP in managing complex oral biofilm-related infections.
抗生素耐药性的增加以及传统疗法在治疗生物膜相关口腔感染方面的局限性凸显了对新解决方案的迫切需求，低温等离子体（LTP）因其强大的抗菌作用、组织安全性和较低的产生耐药性风险而成为一种有前景的替代方法。本综述调查了LTP应用于治疗与龋齿、种植体周围炎、牙髓感染和口腔念珠菌病相关的口腔生物膜的疗效。本综述按照PRISMA-ScR指南进行，并在开放科学框架（OSF）上进行了注册。通过全面检索PubMed/MEDLINE、EBSCO（Medline Ultimate和电子期刊）和谷歌学术搜索来识别研究，无出版日期限制，并通过手动参考文献筛选进行补充。符合条件的研究包括以英文发表的关于LTP在口腔生物膜中有效性的原创研究。在对文献进行系统筛选后，本综述纳入了51项研究，其中大部分是体外研究，还有离体、原位和临床研究。数据提取揭示了LTP的广谱抗菌潜力及其在牙科领域有前景的临床意义。本综述突出了关键发现；确定了研究空白，并强调了LTP在治疗复杂的口腔生物膜相关感染方面的治疗潜力。
