Yoo Jinhee, Heo Dasom, Hwang Yunhee, Kim Chulhong, Park Byullee
Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, Chemical Engineering, Medical Science and Engineering, Graduate School of Artificial Intelligence, and Medical Device Innovation Center, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
Nanomaterials (Basel). 2025 Jun 7;15(12):884. doi: 10.3390/nano15120884.
The cell membrane plays a critical role in regulating substance exchange, signal transduction, and energy conversion, making it essential for maintaining homeostasis and responding to environmental stimuli. Ultrasound is a non-invasive, low-toxic modality that penetrates deep tissues, offering a promising alternative to traditional physical stimuli for advancing cell membrane research. This review focuses on the approaches by which ultrasound interacts with cell membranes and highlights its diverse biomedical applications. Key approaches of ultrasound-membrane interaction include cavitation, sonoporation, and mechanotransduction, which have been harnessed in drug delivery, therapeutics, and diagnostics. Furthermore, we discuss current challenges and future directions to advance the clinical and research potential of this field. Ultrasound-mediated membrane modulation serves as a bridge between fundamental biological studies and clinical translation.
细胞膜在调节物质交换、信号转导和能量转换方面发挥着关键作用，使其对于维持体内平衡和响应环境刺激至关重要。超声是一种非侵入性、低毒性的方式，可穿透深层组织，为推进细胞膜研究提供了一种有前景的替代传统物理刺激的方法。本综述重点关注超声与细胞膜相互作用的方式，并突出其多样的生物医学应用。超声-膜相互作用的关键方式包括空化、声孔效应和机械转导，这些已被应用于药物递送、治疗和诊断。此外，我们讨论了当前的挑战和未来的方向，以提升该领域的临床和研究潜力。超声介导的膜调节作为基础生物学研究与临床转化之间的桥梁。
