Lo Chi Ngai, Wong Nicole Elizabeth Jing Wen, Ho Shina, Ang Elicia Jia Hui, Leung Bernard Pui Lam
Family Care Physiotherapy Clinic, 154 West Coast Road, 85 West Coast Plaza, 01-86, Singapore 127371, Singapore.
Health and Social Sciences, Singapore Institute of Technology, 10 Dover Drive, Singapore 138683, Singapore.
Sports (Basel). 2025 May 29;13(6):168. doi: 10.3390/sports13060168.
This systematic review and meta-analysis aimed to investigate the effectiveness of exercise interventions in regulating inflammatory biomarkers among individuals with musculoskeletal pain. A comprehensive search of MEDLINE, CINAHL, Web of Science, Cochrane Library, and Google Scholar was conducted from inception to November 2024. Only randomized controlled trials (RCTs) published in English that examined the effects of exercise on inflammatory markers-such as C-reactive protein (CRP), interleukins (ILs), and tumor necrosis factor-alpha (TNF-α)-were included. Twenty-three RCTs involving 1128 participants met the inclusion criteria. Meta-analysis of four studies indicated that isokinetic exercise significantly reduced CRP (MD = -0.40, 95% CI: -0.44 to -0.36, < 0.01, I = 0%), IL-6 (MD = -1.59, 95% CI: -2.61 to -0.56, < 0.01, I = 97%), and TNF-α (MD = -4.24, 95% CI: -5.13 to -3.36, < 0.01, I = 90%) levels compared to general exercise. These findings suggest that exercise, particularly isokinetic exercise, may reduce systemic inflammation in patients with musculoskeletal pain and provide therapeutic effects beyond mechanical improvement. The review followed PRISMA guidelines and was registered on PROSPERO (CRD42024500081).
本系统评价和荟萃分析旨在研究运动干预对调节肌肉骨骼疼痛患者炎症生物标志物的有效性。从创刊至2024年11月，对MEDLINE、CINAHL、科学网、Cochrane图书馆和谷歌学术进行了全面检索。仅纳入以英文发表的、研究运动对炎症标志物（如C反应蛋白（CRP）、白细胞介素（ILs）和肿瘤坏死因子-α（TNF-α））影响的随机对照试验（RCTs）。23项涉及1128名参与者的RCTs符合纳入标准。四项研究的荟萃分析表明，与一般运动相比，等速运动显著降低了CRP（MD = -0.40，95%CI：-0.44至-0.36，P < 0.01，I² = 0%）、IL-6（MD = -1.59，95%CI：-2.61至-0.56，P < 0.01，I² = 97%）和TNF-α（MD = -4.24，95%CI：-5.13至-3.36，P < 0.01，I² = 90%）水平。这些发现表明，运动，尤其是等速运动，可能会减轻肌肉骨骼疼痛患者的全身炎症，并提供超出机械改善的治疗效果。本评价遵循PRISMA指南，并在PROSPERO（CRD42024500081）上进行了注册。
