Amoros-Cerón Zayra Yeretzi, Pinos-Rodríguez Juan Manuel, García Hugo Sergio, Olivares-Muñoz Angélica, De Gasperin-López Isaac, Flores-Primo Argel
Facultad de Medicina Veterinaria y Zootecnia, Universidad Veracruzana, Veracruz 91710, Mexico.
Unidad de Investigación y Desarrollo en Alimentos, Tecnológico Nacional de México campus Veracruz (TecNM), Instituto Tecnológico de Veracruz, Veracruz 91897, Mexico.
Vet Sci. 2025 May 27;12(6):522. doi: 10.3390/vetsci12060522.
Mammary gland tumors in dogs are very common in clinical practice. Betulinic acid is currently a compound considered to have anticancer properties in human mammary tumors via nanoemulsions. In this study, betulinic acid nanoemulsions with a particle size of less than 300 nm were prepared. Biopsies were obtained from five female dogs with mammary tumors for histopathological analysis, confirming that two were tubular mammary carcinomas (MMTs, malignant) and three were complex mammary adenomas (BMTs, benign). The five female dogs were administered with a daily oral dose of nanoemulsion containing 5 mg/kg of betulinic acid for 30 days. Tumor size was measured every 7 days, and the response to treatment was assessed according to RECIST (Response Evaluation Criteria In Solid Tumors) standards. In one of the females with MMTs treated with the nanoemulsion, the tumor size was reduced by approximately 38%, while in the BMT female dogs, the nanoemulsion reduced the tumor size by 25.3%. It was concluded that oral administration of betulinic acid nanoemulsions reduced the size of canine mammary tumors. Experimental studies are still needed to further evaluate this preparation.
乳腺肿瘤在犬类中是临床实践中非常常见的疾病。桦木酸目前是一种被认为通过纳米乳剂对人类乳腺肿瘤具有抗癌特性的化合物。在本研究中，制备了粒径小于300nm的桦木酸纳米乳剂。从五只患有乳腺肿瘤的雌性犬获取活检样本进行组织病理学分析，证实其中两只是管状乳腺癌（MMTs，恶性），三只是复杂乳腺腺瘤（BMTs，良性）。对这五只雌性犬每日口服含5mg/kg桦木酸的纳米乳剂，持续30天。每7天测量肿瘤大小，并根据实体瘤疗效评价标准（RECIST）评估治疗反应。在用纳米乳剂治疗的一只患有MMTs的雌性犬中，肿瘤大小缩小了约38%，而在患有BMTs的雌性犬中，纳米乳剂使肿瘤大小缩小了25.3%。得出的结论是，口服桦木酸纳米乳剂可减小犬乳腺肿瘤的大小。仍需要进行实验研究以进一步评估这种制剂。
