真菌进化过程中霉菌毒素的差异保留与损失
Differential Retention and Loss of a Mycotoxin in Fungal Evolution.
作者信息
Chen Lin, Yan Ziying, Yang Bolei, Tai Bowen, Li Weizhao, Li Erfeng, Wang Gang, Xing Fuguo
机构信息
Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou 450006, China.
Key Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
出版信息
Toxins (Basel). 2025 Jun 19;17(6):311. doi: 10.3390/toxins17060311.
Ochratoxin A (OTA) is designated as a mycotoxin and is regulated worldwide due to its harmful effects on humans and animals, but the evolutionary history and ecological significance of OTA in fungi remain poorly understood. Phylogenetic analysis suggested that and obtained an ancient OT cluster, which evolved independently, followed by horizontal OT transfer from to . The varying presence of functional, absent and pseudogenized OT genes across species revealed that this cluster is undergoing a degeneration process in this genus. Furthermore, the cyclase OtaY in the OTA cluster is likely derived from bacteria, which was revealed by phylogenetic analysis. This is the first attempt to investigate the ecological significance of OTA in fungi, suggesting that it may be nonfunctional in spp. and has undergone multiple forms of loss during evolution.
赭曲霉毒素A（OTA）被认定为一种霉菌毒素，由于其对人类和动物具有有害影响，因此在全球范围内受到监管，但OTA在真菌中的进化历史和生态意义仍知之甚少。系统发育分析表明，[具体物种1]和[具体物种2]获得了一个古老的OTA基因簇，该基因簇独立进化，随后从[具体物种1]水平转移至[具体物种2]。跨[具体属]物种的功能性、缺失和假基因化OTA基因的不同存在情况表明，该基因簇在该属中正在经历一个退化过程。此外，OTA基因簇中的环化酶OtaY可能源自细菌，这是通过系统发育分析揭示的。这是首次尝试研究OTA在真菌中的生态意义，表明它在[具体物种]中可能无功能，并且在进化过程中经历了多种形式的丢失。
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