Friedman H, Greenblatt D J
J Clin Pharmacol. 1985 Sep;25(6):448-51. doi: 10.1002/j.1552-4604.1985.tb02875.x.
Sixteen healthy male volunteers received a single oral dose of 25 mg doxylamine succinate. Doxylamine concentrations in plasma were measured by a newly developed gas chromatographic methodology, utilizing direct alkaline extraction into hexane:isoamyl alcohol followed by concentration and autoinjection. Doxylamine kinetics were determined from multiple plasma doxylamine concentrations measured during the 24 hours postdose. Mean kinetic variables were: peak plasma level, 99 ng/mL; time of peak, 2.4 hours postdose; elimination half-life, 10.1 hours; and apparent oral clearance, 217 mL/min. Analogous analytic methodology can be used to study the pharmacokinetics of other drugs of this class.
16名健康男性志愿者单次口服25毫克琥珀酸多西拉敏。血浆中的多西拉敏浓度通过一种新开发的气相色谱方法测定，该方法采用直接碱性萃取到己烷：异戊醇中，然后进行浓缩和自动进样。多西拉敏动力学由给药后24小时内多次测量的血浆多西拉敏浓度确定。平均动力学变量为：血浆峰值水平99纳克/毫升；峰值时间为给药后2.4小时；消除半衰期为10.1小时；表观口服清除率为217毫升/分钟。类似的分析方法可用于研究此类其他药物的药代动力学。
