Satoh K, Fibiger H C
J Comp Neurol. 1985 Jun 8;236(2):215-33. doi: 10.1002/cne.902360206.
The topographic distribution of central cholinergic and catecholaminergic neurons has been investigated in the baboon (Papio papio). The perikarya were mapped on an atlas through the brain and spinal cord employing sections processed for acetylcholinesterase (AChE) pharmacohistochemistry coupled with choline acetyltransferase (ChAT) immunohistochemistry or aqueous catecholamine-fluorescence histochemistry. Compared with subprimates, there is a remarkable increase in the volume occupied by and the number of cholinergic cells contained in the nucleus basalis and nucleus tegmenti pedunculopontinus (subnucleus compacta). The elaboration of these parts of the cholinergic system is accompanied by a large extension of catecholaminergic cell groups in the midbrain (groups A8-A10), particularly the substantia nigra (pars compacta), and in the dorsolateral pontine tegmentum (A5-A7 complex). Although cholinergic and catecholaminergic soma generally occupy distinctly different regions of the brain, a close apposition of cholinergic and noradrenergic neurons occurs in the dorsolateral pontine tegmentum. In the peripeduncular region ChAT-positive cells and green fluorescent neurons of the A6-A7 complex form parallel lines and do not intermingle as has previously been demonstrated in the cat. Two distribution patterns, aggregated or disseminated, are another common feature of central cholinergic and catecholaminergic perikarya. The cholinergic neurons in the nucleus tegmenti pedunculopontinus and the catecholaminergic neurons in A6-A7 complex display both patterns. This comparative study of three transmitter systems in the baboon suggests that the cholinergic as well as the catecholaminergic neurons that give rise to ascending telencephalic and dorsal diencephalic projections undergo phylogenetic development in terms of cell number and nuclear volume.
在狒狒（巴氏狒狒）中对中枢胆碱能和儿茶酚胺能神经元的拓扑分布进行了研究。通过对乙酰胆碱酯酶（AChE）药物组织化学结合胆碱乙酰转移酶（ChAT）免疫组织化学或水性儿茶酚胺荧光组织化学处理的切片，将核周体绘制在贯穿大脑和脊髓的图谱上。与灵长类以下动物相比，基底核和脚桥被盖核（致密亚核）中胆碱能细胞所占的体积和数量显著增加。胆碱能系统这些部分的细化伴随着中脑（A8 - A10组），特别是黑质（致密部）以及背外侧脑桥被盖（A5 - A7复合体）中儿茶酚胺能细胞群的大量扩展。尽管胆碱能和儿茶酚胺能胞体通常占据大脑中明显不同的区域，但在背外侧脑桥被盖中胆碱能和去甲肾上腺素能神经元紧密相邻。在脚周区域，A6 - A7复合体的ChAT阳性细胞和绿色荧光神经元形成平行线，并不像先前在猫中所证明的那样相互混合。聚集或分散的两种分布模式是中枢胆碱能和儿茶酚胺能核周体的另一个共同特征。脚桥被盖核中的胆碱能神经元和A6 - A7复合体中的儿茶酚胺能神经元都呈现这两种模式。对狒狒中三种递质系统的这项比较研究表明，产生向端脑和背侧间脑投射的胆碱能以及儿茶酚胺能神经元在细胞数量和核体积方面经历了系统发育的发展。
