Hurley James H, Coyne Alyssa N, Miączyńska Marta, Stenmark Harald
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.
Nature. 2025 Jun 25. doi: 10.1038/s41586-025-08950-y.
The endosomal sorting complex required for transport (ESCRT) is a multicomplex machinery comprising proteins that are conserved from bacteria to humans and has diverse roles in regulating the dynamics of cellular membranes. ESCRT functions have far-reaching consequences for cell biological processes such as intracellular traffic, membrane repair, cell signalling, metabolic regulation, cell division and genome maintenance. Here we review recent insights that emphasize the pathophysiological consequences of ESCRT dysfunctions, including infections, immune disorders, cancers and neurological diseases. We highlight the possibilities of using our knowledge about ESCRT structures and functions for drug discovery.
转运所需的内体分选复合物（ESCRT）是一种多蛋白复合物机制，其包含从细菌到人类都保守的蛋白质，并且在调节细胞膜动力学方面具有多种作用。ESCRT的功能对细胞生物学过程有着深远影响，如细胞内运输、膜修复、细胞信号传导、代谢调节、细胞分裂和基因组维持。在这里，我们综述了近期的一些见解，这些见解强调了ESCRT功能障碍的病理生理后果，包括感染、免疫紊乱、癌症和神经疾病。我们强调了利用我们对ESCRT结构和功能的了解来进行药物发现的可能性。
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