Zhang Ning, Wang Yusong, Li Fachuang, Zhu Yuxin, Fu Zheng, Jia Mengda, Zhan Xiaoran, Zhang Wanqing
School of Materials Science and Engineering, Henan Institute of Technology, Xinxiang 453003, China.
School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China.
Biomolecules. 2025 Jun 12;15(6):858. doi: 10.3390/biom15060858.
Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality rates globally, presenting a severe threat to human health and life. Acute myocardial infarction (AMI) is one of the most common and extremely severe disorders within CVDs, causing an estimated 17.5 million deaths each year. Cardiac troponin I (cTnI) is considered a biomarker for myocardial infarction and a "gold standard" method for diagnosing AMI due to its high specificity and sensitivity. The ability to rapidly detect cTnI with high sensitivity is critical throughout the diagnosis and treatment process of AMI. It is a necessary precursor for doctors to quickly assess the disease and initiate subsequent therapies. This work comprehensively explores various techniques for the analysis and detection of cTnI. We systematically review current cutting-edge technologies used for cTnI detection. According to optical, electrical, and intelligent technology dimensions, this study meticulously classifies and elaborates on the research progress of related sensors. Based on current research findings and technological development trends, we further project the future research directions and application prospects of cTnI sensors. This is geared towards providing valuable references for the further development of this field.
心血管疾病（CVDs）是全球发病率和死亡率的主要原因之一，对人类健康和生命构成严重威胁。急性心肌梗死（AMI）是心血管疾病中最常见且极其严重的病症之一，每年估计导致1750万人死亡。心肌肌钙蛋白I（cTnI）因其高特异性和敏感性，被认为是心肌梗死的生物标志物和诊断AMI的“金标准”方法。在AMI的整个诊断和治疗过程中，快速、高灵敏度地检测cTnI的能力至关重要。这是医生快速评估病情并启动后续治疗的必要前提。本工作全面探讨了分析和检测cTnI的各种技术。我们系统地综述了当前用于cTnI检测的前沿技术。根据光学、电学和智能技术维度，本研究对相关传感器的研究进展进行了细致分类和阐述。基于当前的研究成果和技术发展趋势，我们进一步预测了cTnI传感器的未来研究方向和应用前景。这旨在为该领域的进一步发展提供有价值的参考。
