Orosz Ferenc
Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, 1117 Budapest, Hungary.
Biology (Basel). 2025 May 28;14(6):620. doi: 10.3390/biology14060620.
Apicortin, a tubulin/microtubule-binding protein, was first described in 2009 as a protein characteristic of apicomplexans; it was found to be present in all Apicomplexa genomes already sequenced. Apart from these, it was found only in , the only known representative of Placozoa at the time. Subsequent analyses revealed that it is present in both closely and distantly related taxa of Apicomplexa (Chrompodellids, Squirmids, Dinoflagellates, and Perkinsids, i.e., in Myzozoa). On the other hand, it turned out that it is also present in early-branching fungi that reproduce by zoospores. Now, we have shown that apicortin is found in many deep-branching opisthokonts. In addition to these fungi and , it is also present in other simple animals, including further Placozoa and Ctenophora, and another opisthokont clade, choanoflagellates. However, apicortin-homologous sequences detected in the genomes/transcriptomes of bilaterian animals are the result of contamination.
顶体蛋白是一种微管蛋白/微管结合蛋白，于2009年首次被描述为顶复门生物的一种特征蛋白；在所有已测序的顶复门基因组中均发现其存在。除此之外，仅在当时所知的扁盘动物唯一代表——盘藻中发现了它。后续分析表明，它存在于顶复门的近缘和远缘类群中（色虫类、旋毛虫类、甲藻和梨形虫类，即粘孢子虫纲）。另一方面，结果表明它也存在于通过游动孢子繁殖的早期分支真菌中。现在，我们已经表明在许多早期分支的后鞭毛生物中发现了顶体蛋白。除了这些真菌和盘藻外，它还存在于其他简单动物中，包括更多的扁盘动物和栉水母，以及另一个后鞭毛生物分支——领鞭毛虫。然而，在两侧对称动物的基因组/转录组中检测到的顶体蛋白同源序列是污染的结果。
