Bagińska-Chyży Joanna, Szymańska Alicja, Korzeniecka-Kozerska Agata
Department of Pediatrics and Nephrology, Medical University of Białystok, 17 Waszyngton Str., 15-274 Białystok, Poland.
Children (Basel). 2025 Jun 9;12(6):748. doi: 10.3390/children12060748.
Myelomeningocele (MMC) is the most severe form of spina bifida, often accompanied by impaired motor function due to paralysis of the lower limbs, as well as neurogenic bladder (NB). These factors may contribute to nutritional disorders and cardiovascular diseases (CVDs) in the future. High-sensitivity CRP (hsCRP) is a positive marker of unstable atherosclerotic plaques and is commonly used in the diagnosis of CVDs. Adiponectin has an opposite, anti-inflammatory function. The aim of this study was to assess the risk of CVDs in a group of children with NB and a control group, based on serum levels of adiponectin, hsCRP, and lipid profiles. : A prospective clinical estimation based on 87 children (67 NB, 20 control group) was conducted. Data collected from medical histories included the following: sex, age, anthropometric parameters (height, weight, BMI), level of spinal lesion, and activity according to Hoffer's scale. Lipid profile values (cholesterol, HDL, LDL, triglycerides) were assessed using standard blood sample tests. hsCRP and adiponectin were measured using an ELISA kit. : A comparison of adiponectin and hsCRP levels revealed statistically significant differences between the NB group and the control. Additionally, significant correlations were identified between BMI and the biomarkers: hsCRP was positively associated with BMI, whereas adiponectin exhibited a negative association. The highest concentrations of hsCRP were detected in MMC patients with a Th lesion level and in non-walker patients. : Elevated hsCRP may reflect increased cardiovascular risk in children with NB. While adiponectin levels were also altered, their association with cardiovascular risk appears more complex and may involve additional metabolic mechanisms.
脊髓脊膜膨出（MMC）是脊柱裂最严重的形式，常因下肢麻痹导致运动功能受损，以及神经源性膀胱（NB）。这些因素可能在未来导致营养失调和心血管疾病（CVD）。高敏C反应蛋白（hsCRP）是不稳定动脉粥样硬化斑块的阳性标志物，常用于CVD的诊断。脂联素具有相反的抗炎功能。本研究的目的是基于脂联素、hsCRP和血脂谱的血清水平，评估一组NB患儿和对照组患CVD的风险。：对87名儿童（67名NB患儿，20名对照组）进行了前瞻性临床评估。从病史中收集的数据包括：性别、年龄、人体测量参数（身高、体重、BMI）、脊柱病变水平以及根据霍弗量表评估的活动情况。血脂谱值（胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯）通过标准血液样本检测进行评估。hsCRP和脂联素使用酶联免疫吸附测定试剂盒进行测量。：脂联素和hsCRP水平的比较显示，NB组和对照组之间存在统计学上的显著差异。此外，还发现BMI与生物标志物之间存在显著相关性：hsCRP与BMI呈正相关，而脂联素呈负相关。在病变水平为胸段的MMC患者和非步行患者中检测到最高浓度的hsCRP。：hsCRP升高可能反映NB患儿心血管风险增加。虽然脂联素水平也发生了改变，但其与心血管风险的关联似乎更为复杂，可能涉及其他代谢机制。
