Department of Physiology and Pharmacology, Afzalipour Medical Faculty, Physiology Research Center and Neuroscience Research Center, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, Doha 29222, Qatar.
Nutrients. 2021 Apr 2;13(4):1180. doi: 10.3390/nu13041180.
Adiponectin (a protein consisting of 244 amino acids and characterized by a molecular weight of 28 kDa) is a cytokine that is secreted from adipose tissues (adipokine). Available evidence suggests that adiponectin is involved in a variety of physiological functions, molecular and cellular events, including lipid metabolism, energy regulation, immune response and inflammation, and insulin sensitivity. It has a protective effect on neurons and neural stem cells. Adiponectin levels have been reported to be negatively correlated with cancer, cardiovascular disease, and diabetes, and shown to be affected (i.e., significantly increased) by proper healthy nutrition. The present review comprehensively overviews the role of adiponectin in a range of diseases, showing that it can be used as a biomarker for diagnosing these disorders as well as a target for monitoring the effectiveness of preventive and treatment interventions.
脂联素（一种由 244 个氨基酸组成的蛋白质，分子量为 28kDa）是一种由脂肪组织（脂肪因子）分泌的细胞因子。现有证据表明，脂联素参与多种生理功能、分子和细胞事件，包括脂质代谢、能量调节、免疫反应和炎症以及胰岛素敏感性。它对神经元和神经干细胞具有保护作用。已有报道称，脂联素水平与癌症、心血管疾病和糖尿病呈负相关，并显示受适当健康营养的影响（即显著增加）。本综述全面概述了脂联素在一系列疾病中的作用，表明它可用作诊断这些疾病的生物标志物，以及监测预防和治疗干预效果的靶标。
