Dejean C B, Oubiña J R, Carballal G, Teyssié A R
Instituto Nacional de Microbiología, Dr. C.G. Malbrán Departamento Virus, Buenos Aires, Argentina.
J Med Virol. 1988 Jan;24(1):97-9. doi: 10.1002/jmv.1890240112.
The interferon (IFN) induction capacity of the XJ prototype strain of Junín virus (JV) was investigated in the guinea pig model. Circulating alpha IFN was detected in 50% of the animals from days 2 to 9 postinfection (pi) and in 100% at day 11 pi, when all animals were in the premortem stage. Individual levels ranged from 20 to 1,280 guinea pig IFN units (GPIFNU)/ml. A correlation between XJ strain virulence and IFN titers was recorded. A possible role of IFN as a pathogenic factor in the outcome of the disease is discussed.
在豚鼠模型中研究了胡宁病毒（JV）XJ原型株的干扰素（IFN）诱导能力。感染后（pi）第2至9天，50%的动物检测到循环α干扰素，pi第11天所有动物处于濒死期时，100%的动物检测到循环α干扰素。个体水平范围为20至1280豚鼠干扰素单位（GPIFNU）/毫升。记录了XJ株毒力与干扰素滴度之间的相关性。讨论了干扰素作为疾病结局致病因素的可能作用。
