Khalid Noman, Munshi Hasan, Ahmad Abdullah, Abdullah Muhammad, Afzal Muhammad Adil, Qadir Sarshaar, Shamoon Yezin, Vasudev Rahul, Shamoon Fayez E
Department of Internal Medicine, St. Joseph's University Medical Center, Paterson, NJ 07503, USA.
Department of Cardiology, St. Joseph's University Medical Center, Paterson, NJ 07503, USA.
J Clin Med. 2025 Jun 13;14(12):4216. doi: 10.3390/jcm14124216.
This study aimed to examine global hypertensive heart disease (HHD) trends (1990-2019). : We extracted data from the Global Burden of Disease (GBD) 2019 Study, encompassing 204 countries and territories. We analyzed the age-adjusted mortality rates (AAMRs), crude mortality, prevalence, years lived with disability (YLD), years of life lost (YLL), and disability-adjusted life years (DALY). Joinpoint Regression Analysis was used to calculate the Annual Percentage Change (APC), with < 0.05 indicating statistical significance. Results were stratified by region, Socio-Demographic Index (SDI), and gender. : Globally, the crude mortality rate for HHD rose from 12.2 (95% UI 9.9-13.6) to 14.9 (95% UI 16.5-11.1) deaths/100,000 population (1990-2019), whereas the AAMR declined from 19.3 (95% UI 5.8-21.6) to 15.1 (95% UI 11.1-16.7). A Joinpoint Analysis revealed significant APC shifts: a decrease of -1.53% ( < 0.05) from 1990 to 2006, an increase of +0.60% ( < 0.05) from 2006 to 2015, and a subsequent decrease of -1.28% ( < 0.05) from 2006 to 2019. Eastern Europe showed the highest annual rate of change in AAMR at 0.9 (95% UI: -0.1 to 1.2), whereas the high-income Asia Pacific region experienced the largest decline at -0.66 (95% UI -0.27--0.72). Central Asian males had an AAMR of 31.1 (95% UI 35.3-22.9) in 2019, and Sub-Saharan African females reached 38.5 (95% UI 48.4-26.3). YLL trended downward in both sexes (APC: -1.94, < 0.05 in males; -1.81, < 0.05 in females), yet YLD rose steadily in recent years, underscoring a growing chronic burden. The AAMR was highest in 2019 among Sub-Saharan African females, which is a particularly important area. : Targeted strategies are essential to mitigate the escalating HHD burden.
本研究旨在考察全球高血压性心脏病（HHD）的发展趋势（1990 - 2019年）。我们从《2019年全球疾病负担（GBD）研究》中提取数据，该研究涵盖204个国家和地区。我们分析了年龄标准化死亡率（AAMR）、粗死亡率、患病率、伤残调整生命年（YLD）、寿命损失年数（YLL）以及伤残调整生命年（DALY）。采用Joinpoint回归分析来计算年度百分比变化（APC），P < 0.05表示具有统计学意义。结果按地区、社会人口指数（SDI）和性别进行分层。在全球范围内，HHD的粗死亡率从每10万人口12.2例死亡（95% UI 9.9 - 13.6）上升至14.9例死亡（95% UI 16.5 - 11.1）（1990 - 2019年），而AAMR从19.3（95% UI 5.8 - 21.6）降至15.1（95% UI 11.1 - 16.7）。Joinpoint分析显示APC有显著变化：1990年至2006年下降了 - 1.53%（P < 0.05），2006年至2015年上升了 + 0.60%（P < 0.05），随后2015年至2019年下降了 - 1.28%（P < 0.05）。东欧的AAMR年变化率最高，为0.9（95% UI： - 0.1至1.2），而高收入亚太地区下降幅度最大，为 - 0.66（95% UI - 0.27 - - 0.72）。2019年中亚男性的AAMR为31.1（95% UI 35.3 - 22.9），撒哈拉以南非洲女性达到38.5（95% UI 48.4 - 26.3）。YLL在两性中均呈下降趋势（APC：男性为 - 1.94，P < 0.05；女性为 - 1.81，P < 0.05），但近年来YLD稳步上升，凸显了慢性负担的增加。2019年撒哈拉以南非洲女性的AAMR最高，这是一个特别重要的地区。针对性策略对于减轻不断上升的HHD负担至关重要。
