Kiudulaite Inga, Cesarskaja Jelena, Eidininkiene Mante, Pranskuniene Zivile, Pranskunas Andrius
Department of Intensive Care Medicine, Lithuanian University of Health Sciences, Eiveniu g.2, 50161 Kaunas, Lithuania.
Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Sukileliu pr. 13, 50166 Kaunas, Lithuania.
Life (Basel). 2025 May 23;15(6):842. doi: 10.3390/life15060842.
The remote ischemic conditioning (RIC)-induced changes in systemic hemodynamics or circulatory reactivity are unclear. Therefore, we aimed to evaluate the effect of a single bout of RIC on the passive leg raising (PLR)-induced cardiovascular response. This prospective study included 36 healthy volunteers (median age: 24 years). Systemic hemodynamic indices were assessed through the following sequential steps: with the participant in a supine position, during the first PLR maneuver, before RIC, after RIC, during the second PLR maneuver, and with the participant in a supine position. The perfusion index (PI) was measured during PLR before and after RIC. We found no significant differences before and after RIC in the proportion of responders during PLR (participants with stroke volume (SV) change ≥ 10%, 61% vs. 47%, = 0.180). There was a strong correlation between SV changes during the two PLR tests (r = 0.80, < 0.001). PLR significantly increased the PI before and after RIC. However, there was no significant difference before and after RIC in the PLR-induced PI changes ( = 0.944). Our findings suggest that a single bout of RIC has no effect on PLR-induced cardiovascular responses in terms of changes in systemic hemodynamic and peripheral perfusion indices.
远程缺血预处理（RIC）引起的全身血流动力学或循环反应性变化尚不清楚。因此，我们旨在评估单次RIC对被动抬腿（PLR）引起的心血管反应的影响。这项前瞻性研究纳入了36名健康志愿者（中位年龄：24岁）。通过以下连续步骤评估全身血流动力学指标：参与者仰卧位时，在第一次PLR操作期间、RIC之前、RIC之后、第二次PLR操作期间以及参与者仰卧位时。在RIC前后的PLR期间测量灌注指数（PI）。我们发现RIC前后PLR期间反应者的比例没有显著差异（每搏输出量（SV）变化≥10%的参与者，分别为61%和47%，P = 0.180）。两次PLR测试期间的SV变化之间存在很强的相关性（r = 0.80，P < 0.001）。PLR在RIC前后均显著增加了PI。然而，RIC前后PLR引起的PI变化没有显著差异（P = 0.944）。我们的研究结果表明，就全身血流动力学和外周灌注指数的变化而言，单次RIC对PLR引起的心血管反应没有影响。
