Daoudi Hannah, Ferrary Evelyne, Moula Cerine, Agnely Florence, Bochot Amélie, Cailleau Catherine, Nguyen Yann, Lahlou Ghizlène, Torres Renato
Université Paris Cité, Institut Pasteur, AP-HP, Inserm, Fondation Pour l'audition, Institut de l'audition, IHU Re-Connect F-75012, Technologies and Gene Therapy for Deafness Paris France.
ENT Department, Pitié-Salpêtrière, APHP Sorbonne University Paris France.
Laryngoscope Investig Otolaryngol. 2025 Jun 24;10(3):e70190. doi: 10.1002/lio2.70190. eCollection 2025 Jun.
Rodents are used in most otological research studies and the choice of the most appropriate animal model may be crucial in studies of ear diseases and in the development of effective treatments. Here, we used micro-CT to compare temporal bone anatomy between four rodent model animals (guinea pigs, gerbils, rats, and mice) and humans, aiming to better characterize the anatomy of the inner and middle ear, and facial nerve to support informed animal model selection in otologic research.
We generated three-dimensional reconstructions and measured the various middle (tympanic membrane, ossicular chain, and facial nerve) and inner (cochlea, vestibular labyrinth) ear structures.
Each structure of the middle or inner ear of each rodent was described and measured.
This micro-CT analysis of rodents can guide researchers in their choice of the most suitable middle or inner ear models based on the specific anatomic area of interest. Our findings highlight the strengths and limitations of each species, providing essential insight that could enhance the precision and applicability of otological studies.
啮齿动物被用于大多数耳科学研究中，选择最合适的动物模型对于耳部疾病研究和有效治疗方法的开发可能至关重要。在此，我们使用微型计算机断层扫描（micro-CT）比较了四种啮齿动物模型动物（豚鼠、沙鼠、大鼠和小鼠）与人类的颞骨解剖结构，旨在更好地描述内耳、中耳和面神经的解剖结构，以支持耳科学研究中明智地选择动物模型。
我们生成了三维重建图像，并测量了中耳（鼓膜、听骨链和面神经）和内耳（耳蜗、前庭迷路）的各种结构。
描述并测量了每种啮齿动物中耳或内耳的各个结构。
这种对啮齿动物的微型计算机断层扫描分析可以指导研究人员根据感兴趣的特定解剖区域选择最合适的中耳或内耳模型。我们的研究结果突出了每个物种的优势和局限性，提供了重要的见解，可提高耳科学研究的精度和适用性。
4级。
