文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

甘油三酯/高密度脂蛋白和总胆固醇/高密度脂蛋白对新发腹膜透析患者死亡风险和心血管事件的预测价值。

The predictive value of TG/HDL and TC/HDL for risk of mortality and cardiovascular events in incident peritoneal dialysis patients.

作者信息

Ma Tiantian, Gao Shuang, Zhang Beiru, Li Xinqiu, Dong Jie, Bai Yu

机构信息

Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University, Beijing 100034, China.

Key Laboratory of Renal Disease, Ministry of Health, Beijing 100034, China.

出版信息

Clin Kidney J. 2025 May 27;18(6):sfaf165. doi: 10.1093/ckj/sfaf165. eCollection 2025 Jun.

DOI:10.1093/ckj/sfaf165
PMID:40567496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12188193/
Abstract

BACKGROUND: This study investigated the association between triglyceride/high-density lipoprotein cholesterol (TG/HDL-C), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) and clinical outcomes in patients with peritoneal dialysis (PD) through the present prospective cohort study. METHODS: This study is an observational analysis based on PD Telemedicine-assisted Platform Cohort Study. The lipid data was defined as the average levels for the first 3 months after receiving PD, including TG, TG and HDL-C. The primary outcome was all-cause mortality, and the secondary outcomes were major adverse cardiovascular events (MACE), modified MACE+ and hemodialysis transfer. RESULTS: A total of 5875 PD patients were enrolled. By cubic spline regression analysis, the cut-off value of TG/HDL-C and TC/HDL-C were 1.25 and 4.20, respectively. During the follow-up time, 1098 (7.75/100 person-years) patients died, and the leading cause of mortality was cardiovascular diseases [686 (4.85/100 person-years)]. MACE and modified MACE+ occurred in 845 (6.09/100 person-years) and 1459 (10.83/100 person-years) patients, respectively. There were 719 patients (5.08/100 person-years) transferred to hemodialysis. The incidence of all-cause mortality, MACE and modified MACE+ were significant higher in groups with elevated TG/HDL-C and TC/HDL-C ( < .001). CONCLUSIONS: Among patients treated with PD, the elevated TG/HDL-C and TC/HDL-C were independently associated with increased risk of mortality and cardiovascular events.

摘要

背景：本前瞻性队列研究探讨了腹膜透析（PD）患者甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）、总胆固醇/高密度脂蛋白胆固醇（TC/HDL-C）与临床结局之间的关联。 方法：本研究是基于PD远程医疗辅助平台队列研究的观察性分析。脂质数据定义为开始PD治疗后前3个月的平均水平，包括TG、TC和HDL-C。主要结局为全因死亡率，次要结局为主要不良心血管事件（MACE）、改良MACE+和血液透析转换。 结果：共纳入5875例PD患者。通过三次样条回归分析，TG/HDL-C和TC/HDL-C的截断值分别为1.25和4.20。随访期间，1098例（7.75/100人年）患者死亡，主要死亡原因是心血管疾病[686例（4.85/100人年）]。MACE和改良MACE+分别发生在845例（6.09/100人年）和1459例（10.83/100人年）患者中。719例患者（5.08/100人年）转为血液透析。TG/HDL-C和TC/HDL-C升高组的全因死亡率、MACE和改良MACE+发生率显著更高（P<0.001）。 结论：在接受PD治疗的患者中，TG/HDL-C和TC/HDL-C升高与死亡风险和心血管事件增加独立相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/61cbf809ef6d/sfaf165fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/9d11ab3b1ac3/sfaf165fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/5d2b9a339d52/sfaf165fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/b6bded12d8da/sfaf165fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/786fc754ebdb/sfaf165fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/61cbf809ef6d/sfaf165fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/9d11ab3b1ac3/sfaf165fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/5d2b9a339d52/sfaf165fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/b6bded12d8da/sfaf165fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/786fc754ebdb/sfaf165fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5043/12188193/61cbf809ef6d/sfaf165fig5.jpg

相似文献

[1]
The predictive value of TG/HDL and TC/HDL for risk of mortality and cardiovascular events in incident peritoneal dialysis patients.

Clin Kidney J. 2025-5-27

[2]
Triglyceride/high-density lipoprotein cholesterol ratio associates major adverse cardiac and cerebrovascular events: a 13-year prospective cohort study.

Acta Cardiol. 2025-7

[3]
Non-high-density lipoprotein cholesterol outperforms low-density lipoprotein cholesterol in predicting cardiovascular events among high-risk Asians.

J Clin Lipidol. 2025

[4]
Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases.

Cochrane Database Syst Rev. 2025-5-6

[5]
Elevated remnant cholesterol and triglycerides are predictors of increased total mortality in a primary health care population of 327,347 patients.

Lipids Health Dis. 2025-5-24

[6]
The comparative and added prognostic value of biomarkers to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all-cause mortality in patients who undergo noncardiac surgery.

Cochrane Database Syst Rev. 2021-12-21

[7]
Associations of nontraditional lipoprotein ratios with future cardiovascular events in patients with type 2 diabetes mellitus.

World J Diabetes. 2025-6-15

[8]
Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies.

Nutrients. 2022-6-13

[9]
Smoking cessation for secondary prevention of cardiovascular disease.

Cochrane Database Syst Rev. 2022-8-8

[10]
Effects of a gluten-reduced or gluten-free diet for the primary prevention of cardiovascular disease.

Cochrane Database Syst Rev. 2022-2-24

本文引用的文献

[1]
Dyslipidemia in Peritoneal Dialysis: Implications for Peritoneal Membrane Function and Patient Outcomes.

Biomedicines. 2024-10-17

[2]
Cardiovascular Consequences of Uremic Metabolites: an Overview of the Involved Signaling Pathways.

Circ Res. 2024-3

[3]
Lipoproteins, Cholesterol, and Atherosclerotic Cardiovascular Disease in East Asians and Europeans.

J Atheroscler Thromb. 2023-11-1

[4]
Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes.

Front Genet. 2023-2-6

[5]
The effect of total cholesterol/high-density lipoprotein cholesterol ratio on mortality risk in the general population.

Front Endocrinol (Lausanne). 2022

[6]
Hyperlipidemia and mortality in patients on peritoneal dialysis.

BMC Nephrol. 2022-10-24

[7]
Epidemiology of peritoneal dialysis outcomes.

Nat Rev Nephrol. 2022-12

[8]
Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients.

Nutrients. 2021-12-29

[9]
Triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular events in the general population: A systematic review and meta-analysis of cohort studies.

Nutr Metab Cardiovasc Dis. 2022-2

[10]
Dyslipidemia in Chronic Kidney Disease: Contemporary Concepts and Future Therapeutic Perspectives.

Am J Nephrol. 2021

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索