Alves Talita Gabriela Luna, Xavier Pedro Luiz Porfirio, Garnica Taismara Kustro, Rochetti Arina Lázaro, Qazi Talal Jamil, Vendramini Thiago Henrique Annibale, Haddad Felipe, Munir Muhammad, Brunetto Márcio Antonio, Fukumasu Heidge
Laboratory of Comparative and Translational Oncology, Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, Brazil.
Nutrition and Production Department, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center, University of São Paulo (USP), Pirassununga, Brazil.
Front Vet Sci. 2025 Jun 11;12:1484947. doi: 10.3389/fvets.2025.1484947. eCollection 2025.
Lymphoma is one of the most prevalent types of feline cancer. It is characterized as a group of diseases that can affect various organs, such as the gastrointestinal tract, kidneys, thymus, and skin. In feline medicine, the search for alternative treatments is of utmost importance, given the significant number of animals that relapse or are unresponsive to conventional chemotherapy treatment. As an alternative to existing modalities of treatment for a variety of cancers, oncolytic viruses have been studied in the last few years. Those viruses possess a unique ability to target and eliminate cancer cells while simultaneously stimulating an immune response against malignant cells, acting as an immunotherapy. Newcastle Disease Virus (NDV) is an avian paramyxovirus that affects both domestic and wild birds, causing symptoms that range from severe to asymptomatic, depending on the viral strain. Less virulent strains are considered safe for use as a vaccine against Newcastle Disease. In the Oncology field, those strains are also being studied to be used as oncolytic virotherapy for mammals, and several results demonstrate their efficacy and . The present study aimed to explore the oncolytic potential of Newcastle Disease Virus expressing green fluorescent protein (NDV-GFP) in feline lymphoma cells isolated from a FeLV-positive patient with thymic lymphoma. The NDV-GFP infected, replicated, and induced apoptosis in feline lymphoma cells. Therefore, these results provide preliminary evidence of the oncolytic activity of NDV in feline leukemia virus-induced lymphoma.
淋巴瘤是猫科动物中最常见的癌症类型之一。它被定义为一组可影响多种器官的疾病，如胃肠道、肾脏、胸腺和皮肤。在猫科医学中，鉴于大量动物对传统化疗治疗复发或无反应，寻找替代治疗方法至关重要。作为各种癌症现有治疗方式的替代方法，溶瘤病毒在过去几年中得到了研究。这些病毒具有独特的靶向和消除癌细胞的能力，同时刺激针对恶性细胞的免疫反应，起到免疫治疗的作用。新城疫病毒（NDV）是一种禽副粘病毒，可影响家禽和野生鸟类，根据病毒株的不同，其症状从严重到无症状不等。毒性较低的毒株被认为可安全用作新城疫疫苗。在肿瘤学领域，这些毒株也正在被研究用作哺乳动物的溶瘤病毒疗法，一些结果证明了它们的疗效。本研究旨在探讨表达绿色荧光蛋白的新城疫病毒（NDV-GFP）在从一名患有胸腺淋巴瘤的猫白血病病毒阳性患者分离的猫淋巴瘤细胞中的溶瘤潜力。NDV-GFP在猫淋巴瘤细胞中感染、复制并诱导凋亡。因此，这些结果为NDV在猫白血病病毒诱导的淋巴瘤中的溶瘤活性提供了初步证据。
