Tang Jiayong, Wang Yifan, Zhou Qiang, Fang Zhengfeng, Lin Yan, Xu Shengyu, Feng Bin, Zhuo Yong, Jiang Xuemei, Zhao Hua, Wu De, Che Lianqiang
Key Laboratory for Animal Disease-resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan, China.
Front Vet Sci. 2025 Jun 11;12:1574259. doi: 10.3389/fvets.2025.1574259. eCollection 2025.
The antioxidants were found to improve inflammatory responses and redox status. This study investigated the effects of maternal and post-weaning supplementation with microbe-derived antioxidants (MA) on sow performance, redox status, and fecal microorganisms, as well as the growth performance, inflammatory responses and intestinal microbiota of weaned piglets. Sixty multiparous sows were randomly allocated to the control group (CON, basal diet) and the MA group (basal diet supplemented with 2.0 g MA/kg) from d 90 of gestation to d 24 of lactation, according to the parity and body condition. At weaning, a total of 80 piglets per group were selected and randomly assigned to either the basal diet or the MA-supplemented diet, with 10 pens per group and 4 piglets per pen, for a period of 21-day trial. Results showed that maternal MA supplementation increased litter size at weaning ( < 0.05) and the milk contents of dry matter ( = 0.08) and fat ( = 0.09), while decreasing the plasma activities of alanine aminotransferase and aspartate aminotransferase in sows on d 24 of lactation ( < 0.05). Moreover, maternal MA supplementation reduced plasma malondialdehyde concentration ( ≤ 0.01) in sows at farrowing and weaning, as well as catalase activity at weaning ( = 0.01), and tended to increase total antioxidant capacity at farrowing ( = 0.08). Additionally, the fecal contents of butyrate ( = 0.04) and propionate ( = 0.09) were higher in sows receiving the MA diet at d 24 of lactation. In post-weaning piglets, maternal MA supplementation increased average daily gain ( = 0.07) and average daily feed intake ( < 0.05) throughout the period, and increased plasma immunoglobulin G and interleukin-10 concentrations ( < 0.05). Additionally, either maternal or post-weaning MA supplementation positively influenced the gut microbiome of both sows and weaned piglets. In conclusion, maternal MA supplementation during late gestation and lactation increased litter size at weaning, which may be associated with the improved milk quality and redox status. Furthermore, maternal MA supplementation may enhance the growth performance of post-weaning piglets, potentially linking to the improvements in immunological parameters and gut microbiome.
研究发现抗氧化剂可改善炎症反应和氧化还原状态。本研究调查了母体和断奶后补充微生物源抗氧化剂（MA）对母猪生产性能、氧化还原状态和粪便微生物群的影响，以及对断奶仔猪生长性能、炎症反应和肠道微生物群的影响。根据胎次和体况，将60头经产母猪从妊娠第90天至泌乳第24天随机分为对照组（CON，基础日粮）和MA组（基础日粮中添加2.0 g MA/kg）。断奶时，每组选取80头仔猪，随机分配到基础日粮组或添加MA的日粮组，每组10个栏，每栏4头仔猪，进行为期21天的试验。结果表明，母体补充MA可增加断奶时的窝产仔数（P<0.05）以及干物质（P = 0.08）和脂肪（P = 0.09）的乳汁含量，同时降低泌乳第24天母猪血浆中丙氨酸氨基转移酶和天冬氨酸氨基转移酶的活性（P<0.05）。此外，母体补充MA可降低分娩和断奶时母猪血浆丙二醛浓度（P≤0.01）以及断奶时过氧化氢酶活性（P = 0.01），并倾向于增加分娩时的总抗氧化能力（P = 0.08）。另外，在泌乳第24天，采食MA日粮的母猪粪便中丁酸盐（P = 0.04）和丙酸盐（P = 0.09）含量更高．在断奶后仔猪中，母体补充MA可在整个试验期内提高平均日增重（P = 0.07）和平均日采食量（P<0.05），并增加血浆免疫球蛋白G和白细胞介素-10浓度（P<0.05）。此外，母体或断奶后补充MA均对母猪和断奶仔猪的肠道微生物群产生积极影响。总之，妊娠后期和泌乳期母体补充MA可增加断奶时的窝产仔数，这可能与改善乳汁质量和氧化还原状态有关。此外，母体补充MA可能会提高断奶后仔猪的生长性能，这可能与免疫参数和肠道微生物群的改善有关。
