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嗜铬细胞瘤与白塞病:探索一种罕见的共存情况。

Pheochromocytoma and Behçet's Disease: Exploring a Rare Coexistence.

作者信息

Ottu Para Niyas Khalid, Mani Jacob Daya, Ramanathan Nagarajan Divyashri, Viju Diya E, Kakade Anupama

机构信息

Internal Medicine, Burjeel Medical City, Abu Dhabi, ARE.

出版信息

Cureus. 2025 May 26;17(5):e84812. doi: 10.7759/cureus.84812. eCollection 2025 May.

DOI:10.7759/cureus.84812
PMID:40568255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12188282/
Abstract

This case report describes a rare association between pheochromocytoma and Behçet's disease (BD) in a 38-year-old female. The patient presented with palpitations, dizziness, and blood pressure fluctuations, leading to the diagnosis of pheochromocytoma. Following treatment, she developed symptoms of BD, including oral and genital ulcers. This case highlights the challenges in the diagnosis of pheochromocytoma and raises questions about the potential link between catecholamine excess and autoimmune conditions like BD, suggesting a need for further studies into their pathophysiological relationship.

摘要

本病例报告描述了一名38岁女性患者,其嗜铬细胞瘤与白塞病(BD)之间存在罕见关联。该患者出现心悸、头晕和血压波动,从而诊断为嗜铬细胞瘤。治疗后,她出现了BD的症状,包括口腔和生殖器溃疡。本病例突出了嗜铬细胞瘤诊断中的挑战,并引发了关于儿茶酚胺过量与BD等自身免疫性疾病之间潜在联系的问题,提示需要进一步研究它们的病理生理关系。

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1
Pheochromocytoma and Behçet's Disease: Exploring a Rare Coexistence.嗜铬细胞瘤与白塞病:探索一种罕见的共存情况。
Cureus. 2025 May 26;17(5):e84812. doi: 10.7759/cureus.84812. eCollection 2025 May.
2
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本文引用的文献

1
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives.《嗜铬细胞瘤和副神经节瘤的免疫景观:当前进展与展望》
Endocr Rev. 2024 Jul 12;45(4):521-552. doi: 10.1210/endrev/bnae005.
2
The association of Behçet's syndrome with HLA-B51 as understood in 2021.2021 年对 Behçet 综合征与 HLA-B51 关联性的认识。
Curr Opin Rheumatol. 2022 Jan 1;34(1):4-9. doi: 10.1097/BOR.0000000000000846.
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Behçet syndrome.白塞综合征。
Nat Rev Dis Primers. 2021 Sep 16;7(1):67. doi: 10.1038/s41572-021-00301-1.
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Pheochromocytoma.嗜铬细胞瘤
Endocr Regul. 2019 Jul 1;53(3):191-212. doi: 10.2478/enr-2019-0020.
5
Cancer risk in patients with Behçet disease: A nationwide population-based dynamic cohort study from Korea.韩国全国基于人群的动态队列研究:贝切特病患者的癌症风险。
J Am Acad Dermatol. 2018 Mar;78(3):464-470.e2. doi: 10.1016/j.jaad.2017.09.035. Epub 2017 Sep 25.
6
Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.嗜铬细胞瘤和副神经节瘤:内分泌学会临床实践指南
J Clin Endocrinol Metab. 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498.
7
The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria.国际白塞病诊断标准(ICBD):27 个国家对新标准敏感性和特异性的合作研究。
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Pathophysiology of the Behçet's Disease.白塞病的病理生理学
Patholog Res Int. 2012;2012:493015. doi: 10.1155/2012/493015. Epub 2011 Oct 1.
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The neural control of micturition.排尿的神经控制。
Nat Rev Neurosci. 2008 Jun;9(6):453-66. doi: 10.1038/nrn2401.
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New onset systemic lupus erythematosus with pheochromocytoma.新发系统性红斑狼疮合并嗜铬细胞瘤。
J Rheumatol. 2002 Jun;29(6):1334-7.