Perry Kathleen, Yu Miko, Adler Joel T, Maclay Lindsey M, Cron David C, Mohan Sumit, Husain Syed A
Department of Nephrology, Columbia University, New York, NY 10032, United States.
Department of Surgery and Perioperative Care, Dell Medical School, University of Texas at Austin, Austin, TX 78701, United States.
World J Nephrol. 2025 Jun 25;14(2):101419. doi: 10.5527/wjn.v14.i2.101419.
Private insurance coverage is associated with higher rates of living donor kidney transplantation (LDKT) but whether this is attributable to confounding is not known.
To study the association between increased access to private health insurance and LDKT.
Retrospective cohort study using United States transplant registry data. We identified incident candidates aged 22-29 years who were waitlisted for a kidney-only transplant from 2005-2014, excluding prior transplant recipients and those with missing data. We calculated the hazard of LDKT after waitlisting for those with private insurance other insurance pre-Affordable Care Act (ACA) post-ACA, using death and delisting as competing events, for candidates affected by the policy change (age 22-25 years) those who were not (age 26-29 years).
A total of 13817 candidates were included, of whom 46% were age 22-25 years and 54% were age 26-29 years. Among candidates aged 22-25 years at listing, those listed post-ACA were more likely to have private insurance compared to those listed pre-ACA (42% 35%), but there was no difference in private insurance coverage between eras among candidates aged 26-29 years at listing. In adjusted competing risk regression, privately insured patients age 22-25 years were less likely to receive a LDKT post-ACA compared to pre-ACA [hazard ratio (HR) = 0.88, 95%CI: 0.78-1.00], as were those aged 22-25 years old with other insurance types (HR = 0.80, 95%CI: 0.69-0.92). These associations were not seen among candidates age 26-29 years.
Candidates age 22-25 years were likelier to have private insurance post-ACA, without an increased rate in LDKT. Demonstrations of associations between insurance and LDKT are likely attributable to residual confounding.
私人保险覆盖范围与活体供肾移植(LDKT)的较高发生率相关,但这是否归因于混杂因素尚不清楚。
研究获得私人健康保险机会增加与LDKT之间的关联。
使用美国移植登记数据进行回顾性队列研究。我们确定了2005年至2014年期间等待仅肾脏移植的22至29岁的新发候选者,排除既往移植受者和数据缺失者。我们计算了在等待名单上有私人保险、《平价医疗法案》(ACA)实施前有其他保险、ACA实施后的患者接受LDKT的风险,将死亡和从等待名单中除名作为竞争事件,分别针对受政策变化影响的候选者(22至25岁)和未受影响的候选者(26至29岁)进行计算。
共纳入13817名候选者,其中46%为22至25岁,54%为26至29岁。在列入名单时年龄为22至25岁的候选者中,与ACA实施前列入名单的相比,ACA实施后列入名单的更有可能拥有私人保险(42%对35%),但在列入名单时年龄为26至29岁的候选者中,不同时期的私人保险覆盖范围没有差异。在调整后的竞争风险回归中,与ACA实施前相比,22至25岁有私人保险的患者在ACA实施后接受LDKT的可能性较小[风险比(HR)=0.88,95%置信区间:0.78 - 1.00],有其他保险类型的22至25岁患者也是如此(HR = 0.80,95%置信区间:0.69 - 0.92)。在26至29岁的候选者中未观察到这些关联。
22至25岁的候选者在ACA实施后更有可能拥有私人保险,但LDKT发生率并未增加。保险与LDKT之间关联的表现可能归因于残余混杂因素。