Keith Douglas, Ashby Valarie B, Port Friedrich K, Leichtman Alan B
McGill University Health Center, Royal Victoria Hospital, Department of Medicine, Division of Nephrology, 687 Avenue Des Pins, Montreal, PQ, Canada H3A 1A1.
Clin J Am Soc Nephrol. 2008 Mar;3(2):463-70. doi: 10.2215/CJN.02220507. Epub 2008 Jan 16.
Disparities in time to placement on the waiting list on the basis of socioeconomic factors decrease access to deceased-donor renal transplantation for some groups of patients with end-stage renal disease. This study was undertaken to determine candidate factors that influence duration of dialysis before placement on the waiting list among candidates for deceased-donor renal transplantation in the United States from January 2001 to December 2004 and the impact of Medicare eligibility rules on access.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Access to the waiting list was measured as the percentage of all wait-listed candidates in the Scientific Registry of Transplant Recipients database who were listed before dialysis and by the duration of dialysis before placement on the waiting list. Multivariate logistic and linear regressions were used to determine variables that were predictive of preemptive listing and the duration of dialysis before listing.
The odds for preemptive placement on the waiting list improved during the course of the study period, whereas the median duration of prelisting dialysis did not. The candidate factors that were associated with low rates of preemptive listing and prolonged exposure to prelisting dialysis included Medicare insurance, minority race/ethnicity, and low educational attainment. In patients who were listed after the age of 64 yr, the adverse effect of Medicare insurance on access largely disappeared.
The disparity in dialysis exposure could potentially be diminished by concerted efforts on the part of the nephrology and transplant communities to promote early referral and preemptive placement on the waiting list, by calculating waiting time from the date of initiation of dialysis for patients who are on dialysis at the time of referral, and by relaxing Medicare eligibility requirements.
基于社会经济因素,等待名单上的排队时间存在差异,这使得一些终末期肾病患者获得 deceased-donor 肾移植的机会减少。本研究旨在确定 2001 年 1 月至 2004 年 12 月期间美国 deceased-donor 肾移植候选者中影响等待名单登记前透析时间的候选因素,以及医疗保险资格规则对获取机会的影响。
设计、地点、参与者与测量:将等待名单获取情况衡量为移植受者科学登记数据库中所有等待名单上的候选者在透析前登记的百分比以及等待名单登记前的透析时间。采用多变量逻辑回归和线性回归来确定预测优先登记和登记前透析时间的变量。
在研究期间,等待名单上优先登记的几率有所提高,而登记前透析的中位时间并未改变。与优先登记率低和登记前透析时间延长相关的候选因素包括医疗保险、少数族裔种族以及低教育程度。在 64 岁以后登记的患者中,医疗保险对获取机会的不利影响基本消失。
通过肾脏病学和移植领域的共同努力,促进早期转诊和等待名单上的优先登记,为转诊时正在透析的患者从开始透析之日起计算等待时间,以及放宽医疗保险资格要求,有可能减少透析暴露方面的差异。