Spets Dylan S, Karanian Jessica M, Slotnick Scott D
Department of Psychology and Neuroscience, Boston College, USA.
Department of Psychology, Fairfield University, USA.
Neuroimage Rep. 2021 Aug 5;1(4):100043. doi: 10.1016/j.ynirp.2021.100043. eCollection 2021 Dec.
The constructive process of memory is generally successful; however, it can also lead to memory failures such as false memories. Although true memories and false memories rely on some of the same brain regions, these memory types are also mediated by distinct neural substrates. Of relevance, there is a growing body of evidence that there are sex differences in the brain during true memories. However, no studies have investigated whether there are neural sex differences during false memories. In the current fMRI study, across all subjects, false memories produced activity in the precentral sulcus and superior parietal lobule, replicating previous findings. Males produced greater activity than females in the precuneus, posterior cingulate cortex, parietooccipital sulcus, and fusiform gyrus. Females produced greater activity than males in the medial prefrontal cortex, anterior cingulate cortex, paracentral lobule, supramarginal gyrus, lateral sulcus, cingulate sulcus, the putamen, and V1. An interaction analysis revealed a significant interaction between sex and region with a higher magnitude of activity in the hippocampus for males than females and a higher magnitude of activity in V1 for females than males. The current results suggest that false memories are supported by distinct brain regions and cognitive processes in females and males.
记忆的构建过程通常是成功的；然而，它也可能导致记忆失误，如错误记忆。尽管真实记忆和错误记忆依赖于一些相同的脑区，但这些记忆类型也由不同的神经基质介导。相关的是，越来越多的证据表明，在真实记忆过程中大脑存在性别差异。然而，尚无研究调查错误记忆过程中是否存在神经性别差异。在当前的功能磁共振成像研究中，在所有受试者中，错误记忆在前中央沟和顶上小叶产生了活动，重复了先前的发现。男性在楔前叶、后扣带回皮质、顶枕沟和梭状回中的活动比女性更强烈。女性在内侧前额叶皮质、前扣带回皮质、中央旁小叶、缘上回、外侧沟、扣带沟、壳核和V1中的活动比男性更强烈。一项交互分析显示，性别和脑区之间存在显著交互作用，男性海马体中的活动强度高于女性，而女性V1中的活动强度高于男性。当前结果表明，女性和男性的错误记忆由不同的脑区和认知过程支持。
