Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Beijing University of Chinese Medicine, Beijing 100105, China.
Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Diabetes Res Clin Pract. 2024 Apr;210:111615. doi: 10.1016/j.diabres.2024.111615. Epub 2024 Mar 19.
To evaluate and summarize the association between interleukin (IL) concentrations and diabetes mellitus (DM) and its complications.
Meta-analyses and eligible individual studies of observational studies investigating the associations between IL and DM and its complications were included. The random-effects model was used to estimate the summary effect, and the heterogeneity among studies was assessed using the Q-statistic and the I metric; The Egger's regression and the χ test were used to test for small study effects and excess significance bias.
This overview identified 34 meta-analyses that investigated the association between IL concentrations and DM and its complications. Meta-analyses of prospective studies indicated that elevated circulating IL-6 and IL-1β had predictive value for the incident of type 2 diabetes mellitus (T2DM), type 1 diabetes mellitus (T1DM) as well as gestational diabetes mellitus (GDM), and the overall Hazard Ratio (HR) of T2DM was 1.28 (95 % CI: 1.17, 1.40; P＜0.001) per 1 log pg/ml increment in IL-6 levels, however, there was no correlation between circulating IL-10 levels and DM. Meanwhile, the increased level of IL-6 was significantly associated several diabetic complications (Diabetic kidney disease[DKD], diabetic peripheral neuropathy[DPN], and cognitive impairment[CI]), and for the diabetic retinopathy (DR), the levels of IL-1β, IL-8 and IL-10 in the aqueous humor and vitreous humor, but not the blood were significantly correlated with it.
Multiple ILs, such as the IL-6 and IL-1β, are definitively linked to DM and its complications, and they may be new targets for the diagnosis and treatment, but stronger evidence needs to be confirmed by prospective studies with larger sample sizes and longer observation periods.
评估和总结白细胞介素（IL）浓度与糖尿病（DM）及其并发症的关系。
纳入观察性研究中评估 IL 与 DM 及其并发症之间关联的荟萃分析和合格的个体研究。使用随机效应模型估计汇总效应，并使用 Q 统计量和 I 度量评估研究间的异质性；使用 Egger 回归和 χ 检验检验小样本效应和过度显著性偏倚。
该综述共确定了 34 项荟萃分析，研究了白细胞介素浓度与糖尿病及其并发症之间的关系。前瞻性研究的荟萃分析表明，循环中升高的 IL-6 和 IL-1β 对 2 型糖尿病（T2DM）、1 型糖尿病（T1DM）和妊娠期糖尿病（GDM）的发生具有预测价值，T2DM 的总体风险比（HR）为 1.28（95%可信区间：1.17，1.40；P＜0.001），每增加 1 log pg/ml 的 IL-6 水平，然而，循环中 IL-10 水平与 DM 之间没有相关性。同时，IL-6 水平的升高与多种糖尿病并发症（糖尿病肾病[DKD]、糖尿病周围神经病变[DPN]和认知障碍[CI]）显著相关，对于糖尿病视网膜病变（DR），房水和玻璃体中 IL-1β、IL-8 和 IL-10 的水平与 DR 显著相关，但血液中则不然。
多种白细胞介素，如 IL-6 和 IL-1β，与糖尿病及其并发症明确相关，它们可能是新的诊断和治疗靶点，但需要更大样本量和更长观察期的前瞻性研究提供更强的证据来证实。
