Li Xiang, Lian Jie, Lu Haibo
Department of Outpatient Chemotherapy, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Int J Cancer. 2025 Nov 1;157(9):1763-1771. doi: 10.1002/ijc.70018. Epub 2025 Jun 26.
Tumor-associated macrophages (TAMs) are a critical population of immune cells that infiltrate the tumor microenvironment (TME) and significantly influence cancer progression, prognosis, and treatment. SPP1TAMs represent a tumor-promoting subset of TAMs characterized by their ability to secrete osteopontin, along with various cytokines and chemokines, and to interact with a diverse array of ligands. Within the tumor microenvironment, SPP1TAMs are primarily localized to hypoxic and necrotic regions, as well as along the tumor margins. Studies have shown that SPP1TAMs promote tumor angiogenesis, invasion, metastasis, and immunosuppression. The infiltration of SPP1TAMs has been associated with poor prognosis in cancer patients. Furthermore, their presence may influence disease progression and treatment response. Targeting SPP1TAMs has the potential to reduce immunosuppression and augment immunotherapeutic efficacy, thereby contributing to improved treatment outcomes.
肿瘤相关巨噬细胞（TAM）是浸润肿瘤微环境（TME）的关键免疫细胞群体，对癌症进展、预后和治疗有显著影响。SPP1 TAM是TAM的一个促肿瘤亚群，其特征是能够分泌骨桥蛋白以及各种细胞因子和趋化因子，并能与多种配体相互作用。在肿瘤微环境中，SPP1 TAM主要定位于缺氧和坏死区域以及肿瘤边缘。研究表明，SPP1 TAM促进肿瘤血管生成、侵袭、转移和免疫抑制。SPP1 TAM的浸润与癌症患者的不良预后相关。此外，它们的存在可能影响疾病进展和治疗反应。靶向SPP1 TAM有可能减少免疫抑制并增强免疫治疗效果，从而有助于改善治疗结果。
