Vieira Ibraim V, Fan Victoria H, Wiemer Michael W, Lemoff Brian E, Sood Kishan S, Mussa Maria Julia, Yu Charles Q
Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.
Transl Vis Sci Technol. 2025 Jun 2;14(6):33. doi: 10.1167/tvst.14.6.33.
Electronic technology can add new function to intraocular lenses, including the treatment of corneal blindness. However, it is not known if such an implant can be stably implanted within a living eye over time. This study investigates the long-term stability and safety of an intraocular lens-shaped implant with an embedded electronic microdisplay for potential use in treating corneal blindness.
Five intraocular implants containing a nonfunctional microdisplay and projection optic were surgically implanted into five rabbits after removal of their crystalline lenses. This blocks the natural pathway of light into the eye. The rabbits were monitored over 6 months with photography and biometry to assess the centration and axial stability of the implants.
All implants were successfully implanted and remained stable over the 6-month trial. The average distance from the cornea center was 0.868 ± 0.442 mm at 1 month and 0.851 ± 0.591 mm at 6 months. Anterior chamber depth, representing axial stability, was 4.362 ± 0.213 mm at 1 month and 4.351 ± 0.218 mm at 6 months. While posterior capsular opacification and iris adhesions were observed, no major complications occurred.
This study is the first to demonstrate long-term stability of an intraocular lens-shaped implant containing an electronic display and optical system. These findings suggest that such implants are viable and safe, supporting their potential as a treatment for corneal blindness and other broader applications.
Evidence of safety and stability of electronic intraocular lenses in animals paves the way for the study of this emerging field of medical implants in humans.
电子技术可为人工晶状体增添新功能，包括治疗角膜盲。然而，尚不清楚此类植入物能否长期稳定地植入活眼内。本研究调查一种带有嵌入式电子微型显示器的人工晶状体形状的植入物的长期稳定性和安全性，该植入物有望用于治疗角膜盲。
在摘除五只兔子的晶状体后，通过手术将五个包含无功能微型显示器和投影光学器件的眼内植入物植入它们眼中。这阻断了光线进入眼睛的自然路径。通过摄影和生物测量对兔子进行6个月的监测，以评估植入物的中心定位和轴向稳定性。
所有植入物均成功植入，并且在6个月的试验期内保持稳定。1个月时距角膜中心的平均距离为0.868±0.442毫米，6个月时为0.851±0.591毫米。代表轴向稳定性的前房深度在1个月时为4.362±0.213毫米，6个月时为4.351±0.218毫米。虽然观察到后囊膜混浊和虹膜粘连，但未发生重大并发症。
本研究首次证明了含有电子显示器和光学系统的人工晶状体形状植入物的长期稳定性。这些发现表明此类植入物是可行且安全的，支持其作为角膜盲治疗方法及其他更广泛应用的潜力。
电子人工晶状体在动物体内的安全性和稳定性证据为在人类中研究这一新兴的医疗植入物领域铺平了道路。
