Pandi Anandakumar, Sen Nabendu, Manickam Kalappan Vanitha, Lal Vanita
Department of Biochemistry, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.
Former Research Scholar, Department of Medical Biochemistry, Dr.ALMPGIBMS, Taramani Campus, University of Madras, Chennai, Tamil Nadu, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 26. doi: 10.1007/s00210-025-04394-3.
Morin, a naturally occurring flavonoid found in various fruits and medicinal plants, has long been recognized in ethnopharmacological practices for its therapeutic potential. While its antioxidant and anti-inflammatory properties have been appreciated historically, recent molecular studies have begun to uncover the precise mechanisms underlying its protective actions, particularly in the context of liver toxicity induced by drugs and chemicals. Morin has demonstrated significant hepatoprotective effects through its ability to attenuate oxidative stress, suppress pro-inflammatory cytokines, and regulate apoptotic pathways in hepatocytes. Multiple cellular targets and signaling pathways, including Nrf2/HO-1, NF-κB, MAPK, SphK1/S1P, and ADMA/DDAH, have been shown to be modulated by morin, indicating its multi-faceted protective profile. This review explores the molecular mechanisms of morin to enhance understanding of its therapeutic potential and support its future clinical application against drug- and chemical-induced liver injury.
桑色素是一种天然存在于各种水果和药用植物中的黄酮类化合物，长期以来，其治疗潜力在民族药理学实践中得到认可。虽然其抗氧化和抗炎特性在历史上已得到重视，但最近的分子研究已开始揭示其保护作用的精确机制，特别是在药物和化学物质诱导的肝毒性背景下。桑色素已通过减弱氧化应激、抑制促炎细胞因子以及调节肝细胞凋亡途径，显示出显著的肝保护作用。包括Nrf2/HO-1、NF-κB、MAPK、SphK1/S1P和ADMA/DDAH在内的多个细胞靶点和信号通路已被证明受桑色素调节，表明其具有多方面的保护作用。本综述探讨了桑色素的分子机制，以增进对其治疗潜力的理解，并支持其未来针对药物和化学物质诱导的肝损伤的临床应用。
