Kiran C R, Kumari K Anitha, Nair Sanjeev, Fathahudeen A
Department of Pulmonary Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.
Department of Pulmonary Medicine, Government Medical College, Ernakulam, Kerala, India.
Lung India. 2025 Jul 1;42(4):337-342. doi: 10.4103/lungindia.lungindia_630_24. Epub 2025 Jun 27.
Eosinophils are an integral part of lung defence against microbes. It is also responsible for untoward hyper immune responses responsible for lung diseases including Chronic Obstructive Pulmonary Disease (COPD). To compare COPD patients with high and low Absolute Eosinophil Count (AEC) regarding their frequency of exacerbations, and response to treatment.
Prospective observational study. Patients were divided into 2 groups above and below the mean AEC and followed up for 6 months, during when their frequencies of exacerbations were followed up. At the end of 6 months, symptomatology and lung function were reassessed.
Those with high AEC had a shorter time to first exacerbation. These patients also needed significantly greater number of inpatient admissions during the study period. Fall in FEV1 was also significantly higher in this group. There was no significant difference in changes in BMI, CAT or MMRC scores, between these groups.
Patients with high AEC are at higher risk of exacerbations, as well as loss of lung function.
嗜酸性粒细胞是肺部抵御微生物的重要组成部分。它也会引发不良的过度免疫反应，导致包括慢性阻塞性肺疾病（COPD）在内的肺部疾病。比较绝对嗜酸性粒细胞计数（AEC）高和低的COPD患者的急性加重频率以及对治疗的反应。
前瞻性观察性研究。将患者按AEC均值分为两组，随访6个月，期间跟踪其急性加重频率。6个月末，重新评估症状和肺功能。
AEC高的患者首次急性加重的时间较短。在研究期间，这些患者的住院次数也显著更多。该组的第一秒用力呼气容积（FEV1）下降也显著更高。两组之间的体重指数（BMI）、慢性阻塞性肺疾病评估测试（CAT）或改良英国医学研究委员会（MMRC）评分变化无显著差异。
AEC高的患者急性加重风险更高，肺功能丧失风险也更高。
