TREK-1: a Janus-faced and subcellular location-based regulator of cardiac remodeling in heart failure.
作者信息
Ofosuah Patience, Hong TingTing
机构信息
Department of Pharmacology & Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, United States.
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.
出版信息
Am J Physiol Heart Circ Physiol. 2025 Aug 1;329(2):H303-H305. doi: 10.1152/ajpheart.00444.2025. Epub 2025 Jun 26.
Abstract
摘要
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本文引用的文献
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The two-pore K channel TREK-1 regulates pressure overload-induced cardiac remodeling.双孔钾通道TREK-1调节压力超负荷诱导的心脏重塑。
Am J Physiol Heart Circ Physiol. 2025 Jul 1;329(1):H178-H190. doi: 10.1152/ajpheart.00821.2024. Epub 2025 May 19.
2
IL-37 Modulates Myocardial Calcium Handling via the p-STAT3/SERCA2a Axis in HF-Related Engineered Human Heart Tissue.IL-37 通过 p-STAT3/SERCA2a 轴调节心力衰竭相关工程化人心肌组织中的心肌钙处理。
Adv Healthc Mater. 2024 May;13(13):e2303957. doi: 10.1002/adhm.202303957. Epub 2024 Feb 19.
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In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium-Handling Machinery and Cardiac Function.在遭受慢性应激的小鼠中，外源性cBIN1可维持钙处理机制和心脏功能。
JACC Basic Transl Sci. 2020 May 13;5(6):561-578. doi: 10.1016/j.jacbts.2020.03.006. eCollection 2020 Jun.
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βIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload.βIV- spectrin 通过调控 STAT3 的靶向作用来调节心脏对压力超负荷的反应。
J Clin Invest. 2018 Dec 3;128(12):5561-5572. doi: 10.1172/JCI99245. Epub 2018 Nov 12.
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The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.双孔域钾通道 TREK-1 介导心脏纤维化和舒张功能障碍。
J Clin Invest. 2018 Nov 1;128(11):4843-4855. doi: 10.1172/JCI95945. Epub 2018 Oct 2.
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Front Physiol. 2017 Oct 27;8:852. doi: 10.3389/fphys.2017.00852. eCollection 2017.
7
TREK-1 (K2.1) K channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.TREK-1（K2.1）钾通道在心房颤动和心力衰竭患者中受到抑制，并为节律控制提供治疗靶点。
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