Cândido Flávia Galvão, da Silva Alessandra, Oliveira Nathallia Maria Cotta E, Zanirate Gilmara Alves, Hermsdorff Helen Hermana Miranda
Laboratory of Clinical Analysis and Genomics, Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Viçosa, Avenida PH Rolfs, UFV Campus, s/n, 36570-900 Viçosa, Minas Gerais, Brazil.
Laboratory of Health and Environment Education, Instituto Oswaldo Cruz, Av. Brasil, 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro, Brazil.
Diabetes Res Clin Pract. 2025 Aug;226:112341. doi: 10.1016/j.diabres.2025.112341. Epub 2025 Jun 24.
Relative monocyte count (RMC) is a low-cost widely used biomarker with the potential to predict obesity-related health risks. However, high cardiovascular risk could affect white blood cell dynamics. So, we aimed to investigate the associations between RMC with cardiometabolic risk markers in subjects at secondary prevention.
This cross-sectional survey involved 687 subjects at Secondary Health Care. The cardiometabolic risk markers were obesity, metabolic syndrome, high waist circumference, high waist-to-height ratio, hypertension, diabetes, dyslipidemia, high glycated hemoglobin, waist-hypertriglyceridemic phenotype 1 and 2, visceral adiposity index, atherogenic index of plasma, lipid accumulation product, and deep-abdominal-adipose-tissue. Pearson's chi-square test, binomial, and multiple Logistic regression were adopted (α = 0.05).
The first tertile of RMC (<5.20 %) was associated with higher odds of metabolic syndrome (OR 1.62; 95 %CI 1.10-2.17 for NCEP-ATPIII criteria and OR 1.48; 95 %CI 1.01-2.33 for IDF), diabetes (OR 1.68; 95 %CI 1.02-2.76), high glycated hemoglobin (OR 2.31; 95 %CI 1.16-4.59), hypertriglyceridemia (OR 1.57; 95 %CI 1.02-2.40), and waist-hypertriglyceridemic phenotype 1 (OR 1.58; 95 %CI 1.04-2.40) and 2 (OR 1.83; 95 %CI 1.17-2.88), compared to the third tertile, regardless of confounders.
The lower RMC tertile was associated with higher odds of cardiometabolic disorders in subjects at secondary prevention.
相对单核细胞计数（RMC）是一种低成本且广泛应用的生物标志物，具有预测肥胖相关健康风险的潜力。然而，高心血管风险可能会影响白细胞动态。因此，我们旨在研究二级预防对象中RMC与心脏代谢风险标志物之间的关联。
这项横断面调查涉及687名二级医疗保健对象。心脏代谢风险标志物包括肥胖、代谢综合征、高腰围、高腰高比、高血压、糖尿病、血脂异常、高糖化血红蛋白、腰-高甘油三酯血症表型1和2、内脏脂肪指数、血浆致动脉粥样硬化指数、脂质蓄积产物以及腹部深层脂肪组织。采用Pearson卡方检验、二项式检验和多元逻辑回归（α = 0.05）。
无论混杂因素如何，与第三分位数相比，RMC的第一分位数（<5.20%）与代谢综合征（根据NCEP-ATPIII标准，OR为1.62；95%CI为1.10 - 2.17；根据IDF标准，OR为1.48；95%CI为1.01 - 2.33）、糖尿病（OR为1.68；95%CI为1.02 - 2.76）、高糖化血红蛋白（OR为2.31；95%CI为1.16 - 4.59）、高甘油三酯血症（OR为1.57；95%CI为1.02 - 2.40）以及腰-高甘油三酯血症表型1（OR为1.58；95%CI为1.04 - 2.40）和2（OR为1.83；95%CI为1.17 - 2.88）的较高比值比相关。
在二级预防对象中，较低的RMC分位数与心脏代谢紊乱的较高比值比相关。
