The activity of essential oils (EOs) from Corsican aromatic plants was evaluated using the marine bacterium as a model system. Among the eleven EOs screened, EO showed significant interference with QS-regulated phenotypes (swimming motility, bioluminescence, and biofilm formation). Its activity was compared to EO, known for its high carvacrol content and potent QS inhibition. The fractionation of EO revealed that its most polar fractions exhibited comparable levels of QS-disrupting activity. These chromatographic fractions significantly affected QS-controlled traits, indicating that minor or less volatile compounds may contribute to, or enhance, the overall bioactivity. Furthermore, EO and its polar fractions displayed stronger anti-QS effects against than EO. These results highlight EO as a promising source of natural QS inhibitors and underscore the importance of exploring both complete EOs and their active fractions. This study supports the valorization of Mediterranean endemic flora as a reservoir of bioactive compounds, tested on a model system , and encourages future research on the potential of against clinical bacterial isolates and the development of novel anti-virulence strategies.