Nitescu Viorela Gabriela, Usurelu Diana-Andreea, Olsavszky Teodora, Mihalcea Ana-Maria, Postelnicu Andra, Florea Ruxandra, Stanca Simona, Vivisenco Iolanda Cristina, Petran Madalina Elena, Craciun Maria-Dorina, Chivu Carmen-Daniela, Ulici Alexandru, Ulmeanu Coriolan Emil
Discipline of Pediatrics, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 010221 Bucharest, Romania.
Department of Pediatrics, Grigore Alexandrescu Clinical Emergency Hospital for Children, 011743 Bucharest, Romania.
Microorganisms. 2025 Jun 16;13(6):1405. doi: 10.3390/microorganisms13061405.
Multisystemic inflammatory syndrome in children (MIS-C) is a rare but potentially severe condition that affects multiple organ systems. This study aimed to assess the clinical characteristics and outcomes of patients diagnosed with multisystemic inflammatory syndrome in children (MIS-C) associated with COVID-19. A 12-month prospective study was conducted at the "Grigore Alexandrescu" Clinical Emergency Hospital for Children, Bucharest. This study included children aged 0-18 years who were diagnosed with MIS-C, as defined by the World Health Organization (WHO), the Royal College of Paediatrics and Child Health (RCPCH), and the Centers for Disease Control and Prevention (CDC) criteria. Data on age, gender, clinical and laboratory findings, treatment, and outcomes were analyzed. Follow-up evaluations occurred at one, three, six, nine, and twelve months post-discharge. Among 36 patients (47.3% female, 52.7% male; mean age, 9.9 years), fever and inflammatory syndrome were present in all patients. Other common symptoms included mucocutaneous (63.8%), gastrointestinal (52.7%), cardiac (47.2%), pulmonary (38.8%), and neurological (11.1%) manifestations. At admission, 14/36 were IgM-positive, while 34/36 were IgG-positive. Follow-up revealed sequelae in two patients, including coronary aneurysms and ground-glass pulmonary opacities. Although MIS-C can be severe, most patients had favorable outcomes with proper treatment. Few long-term, organ-specific complications were observed, highlighting the importance of systematic monitoring to ensure full recovery.
儿童多系统炎症综合征（MIS-C）是一种罕见但可能严重的疾病，会影响多个器官系统。本研究旨在评估被诊断为与新冠病毒相关的儿童多系统炎症综合征（MIS-C）患者的临床特征和预后。在布加勒斯特的“格里戈尔·亚历山德雷斯库”儿童临床急救医院进行了一项为期12个月的前瞻性研究。本研究纳入了0至18岁被诊断为MIS-C的儿童，MIS-C的诊断依据世界卫生组织（WHO）、皇家儿科与儿童健康学院（RCPCH）以及疾病控制与预防中心（CDC）的标准。分析了年龄、性别、临床和实验室检查结果、治疗及预后的数据。出院后1、3、6、9和12个月进行随访评估。36例患者中（女性占47.3%，男性占52.7%；平均年龄9.9岁），所有患者均出现发热和炎症综合征。其他常见症状包括皮肤黏膜（63.8%）、胃肠道（52.7%）、心脏（47.2%）、肺部（38.8%）和神经（11.1%）系统表现。入院时，14/36例IgM阳性，34/36例IgG阳性。随访发现2例患者有后遗症，包括冠状动脉瘤和磨玻璃样肺混浊。尽管MIS-C可能很严重，但大多数患者经适当治疗后预后良好。观察到的长期器官特异性并发症很少，这凸显了系统监测以确保完全康复的重要性。
