This paper presents an ultrasonic driving and detection system based on a CMUT array using MEMS technology. Among them, the core component CMUT array is composed of 8 × 8 CMUT array elements, and each CMUT array element contains 6 × 6 CMUT units. The collapse voltage of a single CMUT unit obtained through finite element analysis is 95.91 V, and the resonant frequency is 3.16 MHz. The driving section achieves 64-channel synchronous driving, with key parameters including an adjustable excitation signal frequency ranging from 10 kHz to 5.71 MHz, a delay precision of up to 1 ns, and an excitation duration of eight pulse cycles. For the echo reception, a two-stage amplification circuit for high-frequency weak echoes with 32 channels was designed, achieving a gain of 113.72 dB and -3 dB bandwidth of 3.89 MHz. Simultaneously, a 32-channel analog-to-digital conversion based on a self-calibration algorithm was implemented, with a sampling rate of 50 Mbps and a data width of 10 bits. Finally, the experimental results confirm the successful implementation of the driving system's designed functions, yielding a center frequency of 1.4995 MHz and a relative bandwidth of 127.9%@-6 dB for the CMUT operating in silicone oil. This paper successfully conducted the transmit-receive integrated experiment of the CMUT and applied Butterworth filtering to the echo data, resulting in high-quality ultrasonic echo signals that validate the applicability of the designed CMUT-based system for ultrasonic imaging.