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罗马尼亚的慢性伤口管理:关于实践、方案及富血小板血浆疗效的一项调查

Chronic Wound Management in Romania: A Survey on Practices, Protocols, and PRP Efficacy.

作者信息

Riza Stefania-Mihaela, Porosnicu Andrei-Ludovic, Hariga Cristian-Sorin, Sinescu Ruxandra-Diana

机构信息

Department 11, Discipline Plastic and Reconstructive Surgery, Bucharest Clinical Emergency Hospital, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania.

Department of Plastic Surgery and Reconstructive Microsurgery, Elias Emergency University Hospital, 011461 Bucharest, Romania.

出版信息

Medicina (Kaunas). 2025 Jun 13;61(6):1085. doi: 10.3390/medicina61061085.

DOI:10.3390/medicina61061085
PMID:40572773
Abstract

Chronic wounds pose a significant challenge to healthcare systems, requiring long-term management and multidisciplinary approaches. The absence of a standardized national therapeutic protocol in Romania has resulted in inconsistent clinical practices, which in turn affect treatment efficacy and patient outcomes. The implementation of structured guidelines and the integration of regenerative therapies could enhance the management of chronic wounds. This study employs a cross-sectional observational design to assess the current management strategies among physicians treating chronic wounds and to identify variations in treatment approaches. A 37-question questionnaire was distributed among plastic surgeons, general surgeons, vascular surgeons, and dermatologists via Google Forms. The data collection period spanned one month, resulting in a total of 240 responses from medical centers in Bucharest, Romania. The study found that most physicians treated several cases per week (40.8%) of delayed healing wounds, with the most frequent types being bedsores (57.5%) and diabetic (58.3%) or venous ulcers (55%). Challenges in wound care included patient reluctance, financial constraints, and the psychological burden on caregivers. The most relevant decision factor for surgical treatment was wound stage (86.7%). Most physicians used an initial conservative approach in wound care (52.5%) or did not have a standard approach (44.2%). Around a quarter of respondents (25.8%) used PRP as a treatment method, considering it to have moderate effectiveness (51.6%). The most important factor for encouraging PRP usage was having the necessary equipment for the procedure (72.5%). The most frequently considered benefit in the case of implementing a treatment protocol was increased treatment efficacy (62.5%). Physicians were also highly interested in the use of a standardized treatment protocol (40%). Approximately 41.7% of the physicians expressed a very high interest in having a standardized diagnostic system for chronic wounds. This study highlights that wound care practices remain variable and that the decision-making process is often challenging. There is a moderate belief in the effectiveness of PRP, suggesting that logistical barriers need to be addressed to facilitate access to it. Therapeutic protocols were seen as key to improving care efficacy and consistency, therefore pressing the need for national strategies that support protocol development.

摘要

慢性伤口给医疗系统带来了重大挑战,需要长期管理和多学科方法。罗马尼亚缺乏标准化的国家治疗方案,导致临床实践不一致,进而影响治疗效果和患者预后。实施结构化指南和整合再生疗法可以加强慢性伤口的管理。本研究采用横断面观察设计,以评估治疗慢性伤口的医生当前的管理策略,并确定治疗方法的差异。通过谷歌表单向整形外科医生、普通外科医生、血管外科医生和皮肤科医生发放了一份包含37个问题的问卷。数据收集期为一个月,共收到来自罗马尼亚布加勒斯特医疗中心的240份回复。研究发现,大多数医生每周治疗几例(40.8%)延迟愈合伤口,最常见的类型是褥疮(57.5%)以及糖尿病(58.3%)或静脉溃疡(55%)。伤口护理面临的挑战包括患者抵触、经济限制以及护理人员的心理负担。手术治疗最相关的决定因素是伤口阶段(86.7%)。大多数医生在伤口护理中采用初始保守方法(52.5%)或没有标准方法(44.2%)。约四分之一的受访者(25.8%)使用富血小板血浆(PRP)作为治疗方法,认为其有效性中等(51.6%)。鼓励使用PRP的最重要因素是拥有该 procedure 所需的设备(72.5%)。实施治疗方案时最常考虑的益处是提高治疗效果(62.5%)。医生们对使用标准化治疗方案也高度感兴趣(40%)。约41.7%的医生对拥有慢性伤口标准化诊断系统表示非常感兴趣。本研究强调,伤口护理实践仍然存在差异,决策过程往往具有挑战性。人们对PRP的有效性有一定程度的认可,这表明需要解决后勤障碍以促进其使用。治疗方案被视为提高护理效果和一致性的关键,因此迫切需要支持方案制定的国家战略。

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本文引用的文献

1
The chronic wound characterisation study and biobank: a study protocol for a prospective observational cohort investigation of bacterial community composition, inflammatory responses and wound-healing trajectories in non-healing wounds.慢性伤口特征研究和生物库:一项前瞻性观察队列研究方案,旨在研究非愈合性伤口中细菌群落组成、炎症反应和伤口愈合轨迹。
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Wound Healing Society 2023 update on guidelines for arterial ulcers.2023 年创伤愈合学会关于动脉溃疡治疗指南更新。
Wound Repair Regen. 2024 Sep-Oct;32(5):619-629. doi: 10.1111/wrr.13204. Epub 2024 Jul 17.
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Efficacy of autologous platelet-rich plasma gel in patients with hard-to-heal diabetic foot ulcers: a multicentre study in Japan.
富血小板血浆凝胶治疗难愈合糖尿病足溃疡的疗效:日本多中心研究。
J Wound Care. 2024 Jul 2;33(7):484-494. doi: 10.12968/jowc.2023.0088.
4
Platelet-rich plasma for the treatment of diabetic foot ulcer: a systematic review.富血小板血浆治疗糖尿病足溃疡:系统评价。
Front Endocrinol (Lausanne). 2023 Nov 18;14:1256081. doi: 10.3389/fendo.2023.1256081. eCollection 2023.
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WHS (Wound Healing Society) guidelines update: Diabetic foot ulcer treatment guidelines.伤口愈合协会(WHS)指南更新:糖尿病足溃疡治疗指南。
Wound Repair Regen. 2024 Jan-Feb;32(1):34-46. doi: 10.1111/wrr.13133. Epub 2023 Dec 21.
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The Validity and Reliability of the SINBAD Classification System for Diabetic Foot Ulcers.SINBAD 分类系统用于糖尿病足溃疡的有效性和可靠性。
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7
PRP Versus Standard of Care for Venous leg Ulcers: A Systematic Review and Meta-Analysis of Prospective Comparative Studies.富血小板血浆与下肢静脉溃疡的标准治疗:前瞻性比较研究的系统评价和荟萃分析
Int J Low Extrem Wounds. 2025 Jun;24(2):260-272. doi: 10.1177/15347346221094424. Epub 2022 Apr 14.
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9
Autologous Platelet Rich Plasma Promotes the Healing of Non-Ischemic Diabetic Foot Ulcers. A Randomized Controlled Trial.富血小板血浆促进非缺血性糖尿病足溃疡的愈合。一项随机对照试验。
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