哺乳动物呼肠孤病毒在小鼠体内的基因重配
Genetic reassortment of mammalian reoviruses in mice.
作者信息
Wenske E A, Chanock S J, Krata L, Fields B N
出版信息
J Virol. 1985 Nov;56(2):613-6. doi: 10.1128/JVI.56.2.613-616.1985.
Abstract
Reassortments between type 1 (Lang) and type 3 (Dearing) reoviruses were isolated from suckling mice infected perorally with an inoculum containing both type 1 and type 3 viruses. A total of five distinct reassortants (designated as E1 through E5) were isolated from animals during the course of the experiment. Two reassortants (E1 and E2) represented the majority of the reassortants isolated. The majority of genes of types E1 and E2 were derived from type 1 (Lang). However, E1 had an M2 gene and an S1 gene derived from type 3 (Dearing), while E2 had M2 and S2 genes derived from type 3 (Dearing). Thus, nonrandom reassortment between mammalian reoviruses can be demonstrated in vivo.
摘要
从经口接种含有1型和3型病毒的乳鼠中分离出了1型（Lang）和3型（Dearing）呼肠孤病毒之间的重配病毒。在实验过程中，从动物体内总共分离出了五种不同的重配病毒（命名为E1至E5）。两种重配病毒（E1和E2）占分离出的重配病毒的大部分。E1和E2的大多数基因来源于1型（Lang）。然而，E1有一个来源于3型（Dearing）的M2基因和S1基因，而E2有来源于3型（Dearing）的M2和S2基因。因此，哺乳动物呼肠孤病毒之间的非随机重配可以在体内得到证实。
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