Forster Ashley, Holt David, Durham Amy C
University of Pennsylvania, Philadelphia, PA.
Vet Pathol. 2025 Jun 26:3009858251346221. doi: 10.1177/03009858251346221.
Nasal biopsies from 21 dogs diagnosed with chondro-osseous respiratory epithelial adenomatoid hamartomas or respiratory epithelial adenomatoid hamartomas were reviewed. Associated lesions included angiomatous tissue (4/21), seromucinous gland proliferation (2/21), and polyps (3/21), and all had chronic inflammation. Dogs had epistaxis (14/21), sneezing (9/21), decreased airflow (8/21), congestion (6/21), and discharge (5/21). In addition to a mass lesion, computed tomography findings ( = 19) included turbinate lysis (10/19), cribriform plate and orbit erosion (4/19), and contralateral extension (8/19). In 16 dogs with outcome data collected 0-49 months after diagnosis, 13 had continued respiratory symptoms, 11 of which received medical management; 2 of the 3 dogs with improvement had radiotherapy/radiofrequency procedures after biopsy. Eight dogs were alive, 5 were euthanized due to the hamartoma (median survival 9.3 months), 2 died from unknown causes, and 1 died from a seizure. Nasal hamartomas are often locally destructive mass lesions that cause recurrent upper respiratory symptoms and may require more aggressive therapeutic interventions for disease control. Diagnosing nasal hamartomas requires integrating the clinical history, imaging results, adequate biopsy sampling of the mass, and the presence of characteristic histologic features.
对21只被诊断患有软骨-骨呼吸上皮腺样错构瘤或呼吸上皮腺样错构瘤的犬的鼻活检样本进行了回顾性研究。相关病变包括血管瘤组织（4/21）、浆液黏液性腺增生（2/21）和息肉（3/21），所有病变均伴有慢性炎症。犬出现鼻出血（14/21）、打喷嚏（9/21）、气流减少（8/21）、充血（6/21）和分泌物增多（5/21）。除了肿块病变外，计算机断层扫描结果（n = 19）包括鼻甲溶解（10/19）、筛板和眼眶侵蚀（4/19）以及对侧扩展（8/19）。在16只诊断后0 - 49个月收集了预后数据的犬中，13只持续有呼吸道症状，其中11只接受了药物治疗；3只病情改善的犬中有2只在活检后接受了放疗/射频治疗。8只犬存活，5只因错构瘤实施安乐死（中位生存期9.3个月），2只死因不明，1只死于癫痫发作。鼻错构瘤通常是具有局部破坏性的肿块病变，可导致反复出现的上呼吸道症状，可能需要更积极的治疗干预措施来控制疾病。诊断鼻错构瘤需要综合考虑临床病史、影像学结果、对肿块进行充分的活检取样以及特征性组织学特征的存在情况。
